Detailed information of TA system TA184143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 89184..90094
• Replicon: plasmid pKP2011790
• Accession: NZ_CP066174
• Organism: Klebsiella quasipneumoniae strain KP2011790

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A663AYG0
• Locus tag: JDZ43_RS24690
• Protein ID: WP_004026354.1
• Coordinates: 89184..89654 (-)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A6P1V3Q9
• Locus tag: JDZ43_RS24695
• Protein ID: WP_004026357.1
• Coordinates: 89651..90094 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JDZ43_RS24670	84194..84592	-	399	WP_004212796.1	H-NS histone family protein	-
JDZ43_RS24675	84929..85423	-	495	WP_004212794.1	thermonuclease family protein	-
JDZ43_RS24680	85601..86550	+	950	Protein_85	DUF1173 family protein	-
JDZ43_RS24685	87936..88633	-	698	Protein_86	IS1 family transposase	-
JDZ43_RS24690	89184..89654	-	471	WP_004026354.1	RES family NAD+ phosphorylase	Toxin
JDZ43_RS24695	89651..90094	-	444	WP_004026357.1	DUF2384 domain-containing protein	Antitoxin
JDZ43_RS24700	90195..90698	-	504	Protein_89	DUF4113 domain-containing protein	-
JDZ43_RS24705	90796..91017	-	222	WP_004213643.1	DUF2188 domain-containing protein	-
JDZ43_RS24710	91162..91317	-	156	WP_004213642.1	hypothetical protein	-
JDZ43_RS24715	91392..93518	-	2127	WP_004213640.1	TonB-dependent receptor family protein	-
JDZ43_RS24720	93605..94558	-	954	Protein_93	fec operon regulator FecR	-
JDZ43_RS24725	94555..95076	-	522	WP_004213635.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2	1..210864	210864
	-	flank	IS/Tn	-	-	87936..88439	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17515.79 Da
• Isoelectric Point: 4.6155

>T184143 WP_004026354.1 NZ_CP066174:c89654-89184 [Klebsiella quasipneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T184143 NZ_CP087379:2163335-2163640 [Mannheimia haemolytica]
ATGTTTAACTTAACCGAAGCCCATTTTAGAGATGAAGCTCTTTATCGGTTCTTCCAATATGGCGAAGTCAGCAGAACAAT
CCCTGCTAATCTCACAAGCGTATTAGCTCGCAAACTGGATATGATTAATGCAGCTGAAAAGCTGAATGACTTACGCAGTC
CGCCTGCTAATCGCTTAGAGTTACTTGAGCCGAAACAGAACAACGTCTATTCAATTCGAGTAAACAAACAGTATCGATTG
ATTTTCAAGTTTGAAAACAATGAACTCTCTGATTTATACCTTGACCCACACAATTACGACCTATAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16480.80 Da
• Isoelectric Point: 10.2498

>AT184143 WP_004026357.1 NZ_CP066174:c90094-89651 [Klebsiella quasipneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT184143 NZ_CP087379:2163652-2163972 [Mannheimia haemolytica]
ATGATGCAACGCAAACCGACCCCGGTTGGGGAAATTCTCCAGGAAGAATTTTTAGCGCCACTTAATCTTAAAATCGGCGA
CCTCGTTGAAATTTTAGACGTACACCGCAACACCGCCAGCAACCTTGTGAATAACAGTTGCCGTGTTAGTCCTGAAATGG
CATTTAAATTGGCAAAAGCCTTTGATACCAGCCCTGAATTTTGGCTCAACCTACAAACCGCAACCGATTTATGGGAACTC
CGCCATAACAACCGCTTCCAACAAAGCCTTGATAGCGTAAAAGCCGTAAATCACTGGCAAGGTGTGCCTGCATTTGCTTA
A

Structures

Toxin

• AlphaFold DB: A0A663AYG0

Antitoxin

• AlphaFold DB: A0A6P1V3Q9