Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2482882..2484470 Replicon chromosome
Accession NZ_CP066173
Organism Klebsiella quasipneumoniae strain KP2011790

Toxin (Protein)


Gene name hipA Uniprot ID A0A5Q9LEV0
Locus tag JDZ43_RS12060 Protein ID WP_043519554.1
Coordinates 2482882..2484204 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag JDZ43_RS12065 Protein ID WP_004205921.1
Coordinates 2484204..2484470 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDZ43_RS12025 2477964..2478182 + 219 WP_002904808.1 ParD-like family protein -
JDZ43_RS12030 2478163..2478945 + 783 WP_049093365.1 type I methionyl aminopeptidase -
JDZ43_RS12035 2479214..2480329 + 1116 WP_049115414.1 serine hydrolase -
JDZ43_RS12040 2480316..2480660 + 345 WP_004205915.1 hypothetical protein -
JDZ43_RS12045 2480689..2481222 + 534 WP_004205916.1 hypothetical protein -
JDZ43_RS12050 2481225..2481431 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
JDZ43_RS12055 2481573..2482865 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
JDZ43_RS12060 2482882..2484204 - 1323 WP_043519554.1 type II toxin-antitoxin system HipA family toxin Toxin
JDZ43_RS12065 2484204..2484470 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JDZ43_RS12070 2484753..2485079 - 327 WP_017900379.1 hydroxyisourate hydrolase -
JDZ43_RS12075 2485076..2485576 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JDZ43_RS12080 2485554..2486933 - 1380 WP_023318211.1 purine permease -
JDZ43_RS12085 2487279..2488433 + 1155 WP_117985061.1 FAD-dependent urate hydroxylase HpxO -
JDZ43_RS12090 2488414..2489337 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48998.30 Da        Isoelectric Point: 8.2655

>T184139 WP_043519554.1 NZ_CP066173:c2484204-2482882 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

>T184139 NZ_CP087379:c845967-845635 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT184139 WP_004205921.1 NZ_CP066173:c2484470-2484204 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT184139 NZ_CP087379:c846224-845964 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCATGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References