Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781623..782280 Replicon chromosome
Accession NZ_CP066173
Organism Klebsiella quasipneumoniae strain KP2011790

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag JDZ43_RS03845 Protein ID WP_004205323.1
Coordinates 781870..782280 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JDZ43_RS03840 Protein ID WP_002916312.1
Coordinates 781623..781889 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDZ43_RS03815 776826..778259 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
JDZ43_RS03820 778378..779106 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
JDZ43_RS03825 779156..779467 + 312 WP_049116108.1 N(4)-acetylcytidine aminohydrolase -
JDZ43_RS03830 779630..780289 + 660 WP_004205319.1 hemolysin III family protein -
JDZ43_RS03835 780394..781377 - 984 WP_049116109.1 tRNA-modifying protein YgfZ -
JDZ43_RS03840 781623..781889 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JDZ43_RS03845 781870..782280 + 411 WP_004205323.1 protein YgfX Toxin
JDZ43_RS03850 782287..782808 - 522 WP_004205324.1 flavodoxin FldB -
JDZ43_RS03855 782909..783805 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JDZ43_RS03860 783828..784541 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JDZ43_RS03865 784547..786280 + 1734 WP_117984785.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T184130 WP_004205323.1 NZ_CP066173:781870-782280 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T184130 NZ_CP087377:c4143392-4142994 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT184130 WP_002916312.1 NZ_CP066173:781623-781889 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT184130 NZ_CP087377:c4143688-4143395 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References