Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 241249..241891 Replicon chromosome
Accession NZ_CP066168
Organism Bacillus anthracis strain STI1

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag C6N15_RS01340 Protein ID WP_000635963.1
Coordinates 241541..241891 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag C6N15_RS01335 Protein ID WP_000004570.1
Coordinates 241249..241536 (+) Length 96 a.a.

Genomic Context

C6N15_RS01310C6N15_RS01320C6N15_RS01325C6N15_RS01330C6N15_RS01335C6N15_RS01340C6N15_RS01345C6N15_RS01355C6N15_RS01315C6N15_RS01350
Location: 236565..237527 (963 bp)
Type: Others
Protein ID: WP_000961037.1
Location: 238185..238544 (360 bp)
Type: Others
Protein ID: WP_000635040.1
Location: 238701..239651 (951 bp)
Type: Others
Protein ID: WP_025388382.1
Location: 239770..240939 (1170 bp)
Type: Others
Protein ID: WP_000390596.1
Location: 241249..241536 (288 bp)
Type: Antitoxin
Protein ID: WP_000004570.1
Location: 241541..241891 (351 bp)
Type: Toxin
Protein ID: WP_000635963.1
Location: 241959..244127 (2169 bp)
Type: Others
Protein ID: WP_000426225.1
Location: 244497..244955 (459 bp)
Type: Others
Protein ID: WP_000344248.1
Location: 237520..238092 (573 bp)
Type: Others
Protein ID: WP_000906916.1
Location: 244185..244301 (117 bp)
Type: Others
Protein ID: WP_001143642.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C6N15_RS01310236565..237527+963WP_000961037.1UV DNA damage repair endonuclease UvsE-
C6N15_RS01315237520..238092-573WP_000906916.1rhomboid family intramembrane serine protease-
C6N15_RS01320238185..238544+360WP_000635040.1holo-ACP synthase-
C6N15_RS01325238701..239651+951WP_025388382.1outer membrane lipoprotein carrier protein LolA-
C6N15_RS01330239770..240939+1170WP_000390596.1alanine racemase-
C6N15_RS01335241249..241536+288WP_000004570.1antitoxin EndoAIAntitoxin
C6N15_RS01340241541..241891+351WP_000635963.1type II toxin-antitoxin system endoribonuclease NdoAToxin
C6N15_RS01345241959..244127+2169WP_000426225.1RNA-binding transcriptional accessory protein-
C6N15_RS01350244185..244301-117WP_001143642.1cortex morphogenetic protein CmpA-
C6N15_RS01355244497..244955+459WP_000344248.1SprT family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T184124 WP_000635963.1 NZ_CP066168:241541-241891 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T184124 NZ_CP087377:3040425-3040532 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT184124 WP_000004570.1 NZ_CP066168:241249-241536 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT184124 NZ_CP087377:c3040378-3040312 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4HKE
PDB7BXY

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366FY90

References