Detailed information of TA system TA184123

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3991919..3992444
• Replicon: chromosome
• Accession: NZ_CP066167
• Organism: Spongiibacter sp. CSC3.9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6N98_RS18080
• Protein ID: WP_198569715.1
• Coordinates: 3991919..3992203 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6N98_RS18085
• Protein ID: WP_198569716.1
• Coordinates: 3992193..3992444 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6N98_RS18050	3987003..3987998	+	996	WP_198569709.1	NAD(P)H-quinone oxidoreductase	-
I6N98_RS18055	3988024..3990111	+	2088	WP_198569710.1	ATP-dependent DNA helicase RecG	-
I6N98_RS18060	3990160..3990654	+	495	WP_198569711.1	AAA family ATPase	-
I6N98_RS18065	3990722..3991174	+	453	WP_198569712.1	DMT family transporter	-
I6N98_RS18070	3991423..3991662	+	240	WP_198569713.1	type II toxin-antitoxin system ParD family antitoxin	-
I6N98_RS18075	3991662..3991922	+	261	WP_198569714.1	type II toxin-antitoxin system RelE/ParE family toxin	-
I6N98_RS18080	3991919..3992203	-	285	WP_198569715.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6N98_RS18085	3992193..3992444	-	252	WP_198569716.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I6N98_RS18090	3992599..3993135	-	537	WP_198569717.1	N-acetyltransferase	-
I6N98_RS18095	3993275..3993586	-	312	WP_198569718.1	hypothetical protein	-
I6N98_RS18100	3993605..3994099	-	495	WP_198569719.1	hypothetical protein	-
I6N98_RS18105	3994166..3994834	-	669	WP_198569720.1	HAD family hydrolase	-
I6N98_RS18110	3995431..3995883	-	453	WP_198569721.1	hypothetical protein	-
I6N98_RS18115	3996178..3997143	+	966	WP_198569722.1	integron integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3878421..4067826	189405

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-75)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10937.91 Da
• Isoelectric Point: 10.6154

>T184123 WP_198569715.1 NZ_CP066167:c3992203-3991919 [Spongiibacter sp. CSC3.9]
MTYKLRFLPAALKEWNKLGAPIRSQFKKKLAERLNEPRVQADKLSGYESVYKIKLRSAGYRLAYEVVDDELLVYVLAIGK
REKGKIYSSLKKRT

Nucleotide

• Length: 285 bp

>T184123 NZ_CP087377:c2839035-2838859 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9165.41 Da
• Isoelectric Point: 4.2950

>AT184123 WP_198569716.1 NZ_CP066167:c3992444-3992193 [Spongiibacter sp. CSC3.9]
MRQVLADFSVSISELKKNPSSLLSQASGSPIAVLNHNKPAAYLIPAETYEALMDMIEDYELSKLVEERRGDKEQAIAVSL
DDL

Nucleotide

• Length: 252 bp

>AT184123 NZ_CP087377:c2838813-2838397 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA