Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3991423..3991922 Replicon chromosome
Accession NZ_CP066167
Organism Spongiibacter sp. CSC3.9

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag I6N98_RS18075 Protein ID WP_198569714.1
Coordinates 3991662..3991922 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag I6N98_RS18070 Protein ID WP_198569713.1
Coordinates 3991423..3991662 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6N98_RS18050 3987003..3987998 + 996 WP_198569709.1 NAD(P)H-quinone oxidoreductase -
I6N98_RS18055 3988024..3990111 + 2088 WP_198569710.1 ATP-dependent DNA helicase RecG -
I6N98_RS18060 3990160..3990654 + 495 WP_198569711.1 AAA family ATPase -
I6N98_RS18065 3990722..3991174 + 453 WP_198569712.1 DMT family transporter -
I6N98_RS18070 3991423..3991662 + 240 WP_198569713.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
I6N98_RS18075 3991662..3991922 + 261 WP_198569714.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6N98_RS18080 3991919..3992203 - 285 WP_198569715.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6N98_RS18085 3992193..3992444 - 252 WP_198569716.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
I6N98_RS18090 3992599..3993135 - 537 WP_198569717.1 N-acetyltransferase -
I6N98_RS18095 3993275..3993586 - 312 WP_198569718.1 hypothetical protein -
I6N98_RS18100 3993605..3994099 - 495 WP_198569719.1 hypothetical protein -
I6N98_RS18105 3994166..3994834 - 669 WP_198569720.1 HAD family hydrolase -
I6N98_RS18110 3995431..3995883 - 453 WP_198569721.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3878421..4067826 189405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-64)

Antitoxin

Antitoxin ParD

(4-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10119.71 Da        Isoelectric Point: 10.5492

>T184122 WP_198569714.1 NZ_CP066167:3991662-3991922 [Spongiibacter sp. CSC3.9]
MRPFLLTAVARKDIIDIGRYTTEKWGKRQRDKYLKQLDDAFKMLARQPEIGRDADDVKPGYKKFSQKPQRKSRRCACDCY
AGPRSH

Download         Length: 261 bp

>T184122 NZ_CP087377:2733172-2734494 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8788.76 Da        Isoelectric Point: 4.4915

>AT184122 WP_198569713.1 NZ_CP066167:3991423-3991662 [Spongiibacter sp. CSC3.9]
MARNTSITLGPHFDEFIAAQVKNGRYGSVSEVVRAGLRLLEETESKLDRLRRLLDEGEQSGIADYSLESVIAELDNEAH

Download         Length: 240 bp

>AT184122 NZ_CP087377:2732906-2733172 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References