Detailed information of TA system TA184121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1344570..1345080
• Replicon: chromosome
• Accession: NZ_CP066167
• Organism: Spongiibacter sp. CSC3.9

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6N98_RS06135
• Protein ID: WP_198570910.1
• Coordinates: 1344805..1345080 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: I6N98_RS06130
• Protein ID: WP_198570909.1
• Coordinates: 1344570..1344824 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6N98_RS06115	1341165..1341671	-	507	WP_198570906.1	retroviral-like aspartic protease family protein	-
I6N98_RS06120	1342509..1343519	+	1011	WP_198570907.1	UDP-glucose 4-epimerase GalE	-
I6N98_RS06125	1343905..1344417	+	513	WP_198570908.1	transposase	-
I6N98_RS06130	1344570..1344824	+	255	WP_198570909.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I6N98_RS06135	1344805..1345080	+	276	WP_198570910.1	Txe/YoeB family addiction module toxin	Toxin
I6N98_RS06140	1345289..1346749	-	1461	WP_198570911.1	ATP-binding cassette domain-containing protein	-
I6N98_RS06145	1347372..1349669	-	2298	WP_198570912.1	polysaccharide biosynthesis tyrosine autokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10881.34 Da
• Isoelectric Point: 8.8609

>T184121 WP_198570910.1 NZ_CP066167:1344805-1345080 [Spongiibacter sp. CSC3.9]
MESAKIEILSWTREAWSDYLYWQSQDKKTLKRINKLIRDTQRSPFEGIGKPEPLKESLTGFWSRRIDDTHRLVYAVDSDQ
VTIIACRYHYT

Nucleotide

• Length: 276 bp

>T184121 NZ_CP087377:2383282-2383385 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9274.51 Da
• Isoelectric Point: 8.5817

>AT184121 WP_198570909.1 NZ_CP066167:1344570-1344824 [Spongiibacter sp. CSC3.9]
MKVISFSDARNKLKSVLDQVVNDADYTIISRRGGEDAVVMSLDQFNGLMETVHLLKSPANAAHLSKSIQQYRAGKTKQHG
ISED

Nucleotide

• Length: 255 bp

>AT184121 NZ_CP087377:c2383423-2383152 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT