Detailed information of TA system TA184119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 65848..66404
• Replicon: chromosome
• Accession: NZ_CP066167
• Organism: Spongiibacter sp. CSC3.9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6N98_RS00350
• Protein ID: WP_198569862.1
• Coordinates: 66093..66404 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6N98_RS00345
• Protein ID: WP_198569861.1
• Coordinates: 65848..66105 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6N98_RS00320	61155..63881	+	2727	WP_198569856.1	DNA polymerase I	-
I6N98_RS00325	64359..64673	+	315	WP_198569857.1	HigA family addiction module antidote protein	-
I6N98_RS00330	64788..65066	+	279	WP_198569858.1	toxin	-
I6N98_RS00335	65063..65377	+	315	WP_198569859.1	hypothetical protein	-
I6N98_RS00340	65395..65715	+	321	WP_198569860.1	hypothetical protein	-
I6N98_RS00345	65848..66105	+	258	WP_198569861.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6N98_RS00350	66093..66404	+	312	WP_198569862.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6N98_RS00355	66618..69647	-	3030	WP_198569863.1	efflux RND transporter permease subunit	-
I6N98_RS00360	69647..70918	-	1272	WP_198569864.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	64788..86881	22093

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12060.67 Da
• Isoelectric Point: 4.3068

>T184119 WP_198569862.1 NZ_CP066167:66093-66404 [Spongiibacter sp. CSC3.9]
VAEIIWTDPALDQLEEIAEYIALDKPDAASNLVSQIFSTVERLERFPDSGHVPPELPNSIYRELYVRPCRIFYRQDDELV
FIIHVMREERQLRKLLLSTESDS

Nucleotide

• Length: 312 bp

>T184119 NZ_CP087377:1230349-1230684 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9797.42 Da
• Isoelectric Point: 10.1689

>AT184119 WP_198569861.1 NZ_CP066167:65848-66105 [Spongiibacter sp. CSC3.9]
MKVELVTNLKRQATKILADLHESKEAILITEHGQPSAYLVDVQDYEFMQRRLALLEGLSKGERAILEGKTTSNTKARERM
KKWLK

Nucleotide

• Length: 258 bp

>AT184119 NZ_CP087377:1230101-1230349 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA