Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5407226..5407851 Replicon chromosome
Accession NZ_CP066151
Organism Klebsiella pneumoniae strain KP697

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JDZ44_RS26765 Protein ID WP_002882817.1
Coordinates 5407226..5407609 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JDZ44_RS26770 Protein ID WP_004150355.1
Coordinates 5407609..5407851 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDZ44_RS26750 (JDZ44_26685) 5404592..5405494 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
JDZ44_RS26755 (JDZ44_26690) 5405491..5406126 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JDZ44_RS26760 (JDZ44_26695) 5406123..5407052 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
JDZ44_RS26765 (JDZ44_26700) 5407226..5407609 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JDZ44_RS26770 (JDZ44_26705) 5407609..5407851 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
JDZ44_RS26775 (JDZ44_26710) 5408056..5408973 + 918 WP_002882812.1 alpha/beta hydrolase -
JDZ44_RS26780 (JDZ44_26715) 5408987..5409928 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JDZ44_RS26785 (JDZ44_26720) 5409973..5410410 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
JDZ44_RS26790 (JDZ44_26725) 5410407..5411267 - 861 WP_002882807.1 virulence factor BrkB family protein -
JDZ44_RS26795 (JDZ44_26730) 5411261..5411860 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T184108 WP_002882817.1 NZ_CP066151:c5407609-5407226 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T184108 NZ_CP087355:c17939-17580 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT184108 WP_004150355.1 NZ_CP066151:c5407851-5407609 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT184108 NZ_CP087355:c17580-17281 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References