Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4926991..4927507 Replicon chromosome
Accession NZ_CP066151
Organism Klebsiella pneumoniae strain KP697

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JDZ44_RS24460 Protein ID WP_002886902.1
Coordinates 4926991..4927275 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JDZ44_RS24465 Protein ID WP_002886901.1
Coordinates 4927265..4927507 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDZ44_RS24435 (JDZ44_24370) 4922475..4922738 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
JDZ44_RS24440 (JDZ44_24375) 4922868..4923041 + 174 WP_002886906.1 hypothetical protein -
JDZ44_RS24445 (JDZ44_24380) 4923044..4923787 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JDZ44_RS24450 (JDZ44_24385) 4924144..4926282 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JDZ44_RS24455 (JDZ44_24390) 4926523..4926987 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JDZ44_RS24460 (JDZ44_24395) 4926991..4927275 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JDZ44_RS24465 (JDZ44_24400) 4927265..4927507 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JDZ44_RS24470 (JDZ44_24405) 4927585..4929495 - 1911 WP_004152270.1 PRD domain-containing protein -
JDZ44_RS24475 (JDZ44_24410) 4929518..4930672 - 1155 WP_002886900.1 lactonase family protein -
JDZ44_RS24480 (JDZ44_24415) 4930738..4931478 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T184106 WP_002886902.1 NZ_CP066151:c4927275-4926991 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T184106 NZ_CP087353:5282-5569 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT184106 WP_002886901.1 NZ_CP066151:c4927507-4927265 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT184106 NZ_CP087353:5556-5870 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References