Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4209808..4210427 Replicon chromosome
Accession NZ_CP066151
Organism Klebsiella pneumoniae strain KP697

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JDZ44_RS21020 Protein ID WP_002892050.1
Coordinates 4210209..4210427 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JDZ44_RS21015 Protein ID WP_002892066.1
Coordinates 4209808..4210182 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDZ44_RS21005 (JDZ44_20950) 4204960..4206153 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JDZ44_RS21010 (JDZ44_20955) 4206176..4209322 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
JDZ44_RS21015 (JDZ44_20960) 4209808..4210182 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JDZ44_RS21020 (JDZ44_20965) 4210209..4210427 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JDZ44_RS21025 (JDZ44_20970) 4210586..4211152 + 567 WP_002892030.1 maltose O-acetyltransferase -
JDZ44_RS21030 (JDZ44_20975) 4211124..4211264 - 141 WP_004147370.1 hypothetical protein -
JDZ44_RS21035 (JDZ44_20980) 4211285..4211755 + 471 WP_002892026.1 YlaC family protein -
JDZ44_RS21040 (JDZ44_20985) 4211730..4213181 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JDZ44_RS21045 (JDZ44_20990) 4213282..4213980 + 699 WP_002892021.1 GNAT family protein -
JDZ44_RS21050 (JDZ44_20995) 4213977..4214117 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JDZ44_RS21055 (JDZ44_21000) 4214117..4214380 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T184104 WP_002892050.1 NZ_CP066151:4210209-4210427 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T184104 NZ_CP087351:c3096190-3095801 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT184104 WP_002892066.1 NZ_CP066151:4209808-4210182 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT184104 NZ_CP087351:c3096454-3096197 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References