Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1494554..1495082 Replicon chromosome
Accession NZ_CP066150
Organism Vibrio sp. ED004

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag ITG10_RS24055 Protein ID WP_005377002.1
Coordinates 1494792..1495082 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID K5UYY9
Locus tag ITG10_RS24050 Protein ID WP_004730320.1
Coordinates 1494554..1494802 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG10_RS24020 (ITG10_23715) 1489686..1490288 - 603 WP_017632996.1 DUF922 domain-containing protein -
ITG10_RS24025 (ITG10_23720) 1490430..1491059 - 630 WP_017632997.1 hypothetical protein -
ITG10_RS24030 (ITG10_23725) 1491154..1491833 + 680 Protein_1275 IS110 family transposase -
ITG10_RS24035 1492306..1492731 + 426 WP_248386968.1 site-specific integrase -
ITG10_RS24040 1492712..1493191 + 480 WP_248386969.1 tyrosine-type recombinase/integrase -
ITG10_RS24045 (ITG10_23735) 1493188..1494239 + 1052 Protein_1278 transposase -
ITG10_RS24050 (ITG10_23740) 1494554..1494802 + 249 WP_004730320.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ITG10_RS24055 (ITG10_23745) 1494792..1495082 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ITG10_RS24060 (ITG10_23750) 1495414..1496010 - 597 WP_128815226.1 cell division protein FtsQ -
ITG10_RS24065 (ITG10_23755) 1496172..1498754 - 2583 WP_128644419.1 nitrate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T184090 WP_005377002.1 NZ_CP066150:1494792-1495082 [Vibrio sp. ED004]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T184090 NZ_CP087335:c2911760-2911578 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9109.39 Da        Isoelectric Point: 3.9610

>AT184090 WP_004730320.1 NZ_CP066150:1494554-1494802 [Vibrio sp. ED004]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT184090 NZ_CP087335:c2911485-2911081 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A0L1LA33

References