Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 395939..396498 Replicon chromosome
Accession NZ_CP066150
Organism Vibrio sp. ED004

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ITG10_RS19330 Protein ID WP_017631470.1
Coordinates 395939..396217 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ITG10_RS19335 Protein ID WP_017631471.1
Coordinates 396214..396498 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG10_RS19305 (ITG10_19035) 391224..392729 - 1506 WP_017631466.1 SgrR family transcriptional regulator -
ITG10_RS19310 (ITG10_19040) 392739..393749 - 1011 WP_017631467.1 Gfo/Idh/MocA family oxidoreductase -
ITG10_RS19315 (ITG10_19045) 393867..394766 - 900 WP_017631468.1 homocysteine S-methyltransferase family protein -
ITG10_RS19320 (ITG10_19050) 394902..395099 - 198 Protein_341 IS110 family transposase -
ITG10_RS19325 (ITG10_19055) 395160..395822 + 663 WP_017631469.1 hypothetical protein -
ITG10_RS19330 (ITG10_19060) 395939..396217 - 279 WP_017631470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ITG10_RS19335 (ITG10_19065) 396214..396498 - 285 WP_017631471.1 hypothetical protein Antitoxin
ITG10_RS19340 (ITG10_19070) 396683..397384 + 702 WP_017631472.1 hypothetical protein -
ITG10_RS19345 (ITG10_19075) 397529..398536 + 1008 WP_017631473.1 substrate-binding domain-containing protein -
ITG10_RS19350 (ITG10_19080) 398610..400406 - 1797 WP_017631474.1 phosphogluconate dehydratase -
ITG10_RS19355 (ITG10_19085) 400403..400927 - 525 WP_017631475.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11021.70 Da        Isoelectric Point: 4.1754

>T184089 WP_017631470.1 NZ_CP066150:c396217-395939 [Vibrio sp. ED004]
MILWEEESLNDRERIFEFIYDFNPDAAENADNLIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEDDIIRIM
RVLHQKQKFPMD

Download         Length: 279 bp

>T184089 NZ_CP087335:491759-492148 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCATTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10984.25 Da        Isoelectric Point: 8.0551

>AT184089 WP_017631471.1 NZ_CP066150:c396498-396214 [Vibrio sp. ED004]
MDTRIQFRVDEETKRLAQQMAESQGRTLSGACRELTEQLAEQQRQTLSHDAWLTEQVNLAFEKFDSGTSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT184089 NZ_CP087335:491495-491752 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References