Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2062900..2063416 Replicon chromosome
Accession NZ_CP066149
Organism Vibrio sp. ED004

Toxin (Protein)


Gene name relB Uniprot ID A0A7W4CBI1
Locus tag ITG10_RS09370 Protein ID WP_016768960.1
Coordinates 2063147..2063416 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag ITG10_RS09365 Protein ID WP_005483180.1
Coordinates 2062900..2063154 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG10_RS09340 (ITG10_09260) 2058503..2058904 - 402 WP_017631320.1 type II toxin-antitoxin system death-on-curing family toxin -
ITG10_RS09345 (ITG10_09265) 2058904..2059074 - 171 WP_016784412.1 hypothetical protein -
ITG10_RS09350 (ITG10_09270) 2060163..2061695 + 1533 WP_017631318.1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase -
ITG10_RS09355 (ITG10_09275) 2061995..2062471 + 477 WP_016768962.1 HI0074 family nucleotidyltransferase substrate-binding subunit -
ITG10_RS09360 2062449..2062637 + 189 WP_236610056.1 nucleotidyltransferase domain-containing protein -
ITG10_RS09365 (ITG10_09285) 2062900..2063154 + 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ITG10_RS09370 (ITG10_09290) 2063147..2063416 + 270 WP_016768960.1 Txe/YoeB family addiction module toxin Toxin
ITG10_RS09375 (ITG10_09295) 2063486..2063971 - 486 WP_016768959.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
ITG10_RS09380 (ITG10_09300) 2064117..2065445 - 1329 WP_017631317.1 MATE family efflux transporter -
ITG10_RS09385 (ITG10_09305) 2065663..2065953 + 291 WP_010433998.1 co-chaperone GroES -
ITG10_RS09390 (ITG10_09310) 2066142..2067788 + 1647 WP_017631316.1 chaperonin GroEL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2048953..2063971 15018


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10645.97 Da        Isoelectric Point: 8.8576

>T184088 WP_016768960.1 NZ_CP066149:2063147-2063416 [Vibrio sp. ED004]
MSSRQRLLSWTDDAWDDYLYWQTQDKKTLKRVNKLINDVKRSSFDGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T184088 NZ_CP087334:c6164-5844 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT184088 WP_005483180.1 NZ_CP066149:2062900-2063154 [Vibrio sp. ED004]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT184088 NZ_CP087334:c5851-5579 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAAGGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4CBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References