Detailed information of TA system TA184087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 2058503..2059074
• Replicon: chromosome
• Accession: NZ_CP066149
• Organism: Vibrio sp. ED004

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: ITG10_RS09340
• Protein ID: WP_017631320.1
• Coordinates: 2058503..2058904 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: ITG10_RS09345
• Protein ID: WP_016784412.1
• Coordinates: 2058904..2059074 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG10_RS09315 (ITG10_09225)	2053661..2053954	+	294	WP_248386368.1	hypothetical protein	-
ITG10_RS09320 (ITG10_09240)	2054930..2056285	+	1356	WP_248386369.1	Fic family protein	-
ITG10_RS09325 (ITG10_09245)	2056399..2056911	-	513	Protein_1782	transcriptional regulator	-
ITG10_RS09330 (ITG10_09250)	2056905..2057176	-	272	Protein_1783	DUF4160 domain-containing protein	-
ITG10_RS09335 (ITG10_09255)	2057864..2058034	+	171	WP_017631321.1	hypothetical protein	-
ITG10_RS09340 (ITG10_09260)	2058503..2058904	-	402	WP_017631320.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
ITG10_RS09345 (ITG10_09265)	2058904..2059074	-	171	WP_016784412.1	hypothetical protein	Antitoxin
ITG10_RS09350 (ITG10_09270)	2060163..2061695	+	1533	WP_017631318.1	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-
ITG10_RS09355 (ITG10_09275)	2061995..2062471	+	477	WP_016768962.1	HI0074 family nucleotidyltransferase substrate-binding subunit	-
ITG10_RS09360	2062449..2062637	+	189	WP_236610056.1	nucleotidyltransferase domain-containing protein	-
ITG10_RS09365 (ITG10_09285)	2062900..2063154	+	255	WP_005483180.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
ITG10_RS09370 (ITG10_09290)	2063147..2063416	+	270	WP_016768960.1	Txe/YoeB family addiction module toxin	-
ITG10_RS09375 (ITG10_09295)	2063486..2063971	-	486	WP_016768959.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2048953..2063971	15018

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (9-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14645.51 Da
• Isoelectric Point: 3.6767

>T184087 WP_017631320.1 NZ_CP066149:c2058904-2058503 [Vibrio sp. ED004]
MDIICFPFERVIEINTFILDTEPGMNGAVDIPKLQGALGRIDNAIVYDGLDDIFEIAAKYTASIAVAHALPDANKRTGLM
VALEYLSLNDYELTSDNELLADAVRDLVLADISETDFADILYAQYAQENNLVD

Nucleotide

• Length: 402 bp

>T184087 NZ_CP087331:c2892734-2892552 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCTTTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6359.46 Da
• Isoelectric Point: 10.9273

>AT184087 WP_016784412.1 NZ_CP066149:c2059074-2058904 [Vibrio sp. ED004]
MNKKIESYGVGAVERPRVKATKKLDLSGTYGQQIVKSESKLALRTHRKTFEKLAHM

Nucleotide

• Length: 171 bp

>AT184087 NZ_CP087331:c2892459-2892055 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG