Detailed information of TA system TA184080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4386945..4387765
• Replicon: chromosome
• Accession: NZ_CP066144
• Organism: Escherichia coli strain ZLWT

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: ICI43_RS21010
• Protein ID: WP_001054379.1
• Coordinates: 4386945..4387202 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: ICI43_RS21015
• Protein ID: WP_000123957.1
• Coordinates: 4387214..4387765 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICI43_RS20990	4382492..4383472	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
ICI43_RS20995	4384055..4385161	-	1107	Protein_4115	DNA helicase	-
ICI43_RS21000	4385224..4386371	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
ICI43_RS21005	4386404..4386568	+	165	Protein_4117	GNAT family N-acetyltransferase	-
ICI43_RS21010	4386945..4387202	+	258	WP_001054379.1	YjhX family toxin	Toxin
ICI43_RS21015	4387214..4387765	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
ICI43_RS21020	4387817..4388563	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
ICI43_RS21025	4388691..4388951	+	261	WP_000077645.1	hypothetical protein	-
ICI43_RS21030	4388989..4389105	+	117	Protein_4122	VOC family protein	-
ICI43_RS21035	4389350..4390471	+	1122	WP_000010833.1	M42 family metallopeptidase	-
ICI43_RS21040	4390468..4390746	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
ICI43_RS21045	4390758..4392071	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	4375563..4395986	20423

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T184080 WP_001054379.1 NZ_CP066144:4386945-4387202 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T184080 NZ_CP066144:4386945-4387202 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT184080 WP_000123957.1 NZ_CP066144:4387214-4387765 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT184080 NZ_CP066144:4387214-4387765 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030