184074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3738233..3738851 Replicon chromosome
Accession NZ_CP066144
Organism Escherichia coli strain ZLWT

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ICI43_RS17970 Protein ID WP_001291435.1
Coordinates 3738633..3738851 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ICI43_RS17965 Protein ID WP_000344800.1
Coordinates 3738233..3738607 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI43_RS17955 3733323..3734516 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ICI43_RS17960 3734539..3737688 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
ICI43_RS17965 3738233..3738607 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ICI43_RS17970 3738633..3738851 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
ICI43_RS17975 3739024..3739575 + 552 WP_000102539.1 maltose O-acetyltransferase -
ICI43_RS17980 3739691..3740161 + 471 WP_001304825.1 YlaC family protein -
ICI43_RS17985 3740325..3741875 + 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ICI43_RS17990 3741917..3742270 - 354 WP_000878140.1 DUF1428 domain-containing protein -
ICI43_RS18000 3742649..3742960 + 312 WP_000409908.1 MGMT family protein -
ICI43_RS18005 3742991..3743563 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T184074 WP_001291435.1 NZ_CP066144:3738633-3738851 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T184074 NZ_CP087325:542232-542621 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT184074 WP_000344800.1 NZ_CP066144:3738233-3738607 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT184074 NZ_CP087325:541968-542225 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References