Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5043333..5043849 Replicon chromosome
Accession NZ_CP066143
Organism Klebsiella pneumoniae U-0608239

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag I6N99_RS24850 Protein ID WP_002886902.1
Coordinates 5043565..5043849 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6N99_RS24845 Protein ID WP_002886901.1
Coordinates 5043333..5043575 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6N99_RS24830 (5039361) 5039361..5040101 + 741 WP_002886899.1 KDGP aldolase family protein -
I6N99_RS24835 (5040168) 5040168..5041322 + 1155 WP_023302389.1 lactonase family protein -
I6N99_RS24840 (5041345) 5041345..5043255 + 1911 WP_009486549.1 PRD domain-containing protein -
I6N99_RS24845 (5043333) 5043333..5043575 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6N99_RS24850 (5043565) 5043565..5043849 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6N99_RS24855 (5043853) 5043853..5044317 - 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6N99_RS24860 (5044626) 5044626..5046764 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6N99_RS24865 (5047121) 5047121..5047864 - 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
I6N99_RS24870 (5047867) 5047867..5048040 - 174 WP_032410138.1 hypothetical protein -
I6N99_RS24875 (5048125) 5048125..5048433 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T184053 WP_002886902.1 NZ_CP066143:5043565-5043849 [Klebsiella pneumoniae U-0608239]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T184053 NZ_CP087309:c2166614-2166432 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT184053 WP_002886901.1 NZ_CP066143:5043333-5043575 [Klebsiella pneumoniae U-0608239]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT184053 NZ_CP087309:c2166339-2165935 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References