Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3700962..3701619 Replicon chromosome
Accession NZ_CP066143
Organism Klebsiella pneumoniae U-0608239

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6N99_RS18315 Protein ID WP_002916310.1
Coordinates 3700962..3701372 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6N99_RS18320 Protein ID WP_002916312.1
Coordinates 3701353..3701619 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6N99_RS18295 (3696962) 3696962..3698695 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
I6N99_RS18300 (3698701) 3698701..3699414 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6N99_RS18305 (3699437) 3699437..3700333 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6N99_RS18310 (3700434) 3700434..3700955 + 522 WP_004144730.1 flavodoxin FldB -
I6N99_RS18315 (3700962) 3700962..3701372 - 411 WP_002916310.1 protein YgfX Toxin
I6N99_RS18320 (3701353) 3701353..3701619 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6N99_RS18325 (3701865) 3701865..3702848 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
I6N99_RS18330 (3702999) 3702999..3703658 - 660 WP_002916317.1 hemolysin III family protein -
I6N99_RS18335 (3703822) 3703822..3704133 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6N99_RS18340 (3704183) 3704183..3704911 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6N99_RS18345 (3705030) 3705030..3706463 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T184048 WP_002916310.1 NZ_CP066143:c3701372-3700962 [Klebsiella pneumoniae U-0608239]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T184048 NZ_CP087300:c132672-132409 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT184048 WP_002916312.1 NZ_CP066143:c3701619-3701353 [Klebsiella pneumoniae U-0608239]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT184048 NZ_CP087300:c132422-132159 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References