Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 1885744..1887332 | Replicon | chromosome |
Accession | NZ_CP066143 | ||
Organism | Klebsiella pneumoniae U-0608239 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A486S9S0 |
Locus tag | I6N99_RS09260 | Protein ID | WP_023301940.1 |
Coordinates | 1886010..1887332 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
Locus tag | I6N99_RS09255 | Protein ID | WP_002904790.1 |
Coordinates | 1885744..1886010 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6N99_RS09230 (1880894) | 1880894..1881817 | + | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
I6N99_RS09235 (1881798) | 1881798..1882952 | - | 1155 | WP_040182036.1 | FAD-dependent urate hydroxylase HpxO | - |
I6N99_RS09240 (1883298) | 1883298..1884677 | + | 1380 | WP_004176204.1 | nucleobase:cation symporter-2 family protein | - |
I6N99_RS09245 (1884655) | 1884655..1885155 | + | 501 | WP_040182039.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
I6N99_RS09250 (1885152) | 1885152..1885478 | + | 327 | WP_004143476.1 | hydroxyisourate hydrolase | - |
I6N99_RS09255 (1885744) | 1885744..1886010 | + | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
I6N99_RS09260 (1886010) | 1886010..1887332 | + | 1323 | WP_023301940.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
I6N99_RS09265 (1887349) | 1887349..1888641 | - | 1293 | WP_016946381.1 | glycoside hydrolase family 10 protein | - |
I6N99_RS09270 (1888783) | 1888783..1889787 | - | 1005 | WP_009308876.1 | fimbrial protein | - |
I6N99_RS09275 (1889775) | 1889775..1892276 | - | 2502 | WP_040182042.1 | fimbria/pilus outer membrane usher protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49185.49 Da Isoelectric Point: 7.5358
>T184039 WP_023301940.1 NZ_CP066143:1886010-1887332 [Klebsiella pneumoniae U-0608239]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T184039 NZ_CP087294:c4450314-4450207 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT184039 WP_002904790.1 NZ_CP066143:1885744-1886010 [Klebsiella pneumoniae U-0608239]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT184039 NZ_CP087294:4450371-4450428 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A486S9S0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GXD8 |