184038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 490146..490765 Replicon chromosome
Accession NZ_CP066143
Organism Klebsiella pneumoniae U-0608239

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6N99_RS02335 Protein ID WP_002892050.1
Coordinates 490146..490364 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6N99_RS02340 Protein ID WP_002892066.1
Coordinates 490391..490765 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6N99_RS02300 (486189) 486189..486452 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
I6N99_RS02305 (486452) 486452..486592 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6N99_RS02310 (486589) 486589..487287 - 699 WP_002892021.1 GNAT family protein -
I6N99_RS02315 (487388) 487388..488839 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I6N99_RS02320 (488814) 488814..489284 - 471 WP_040182126.1 YlaC family protein -
I6N99_RS02325 (489305) 489305..489445 + 141 WP_004147370.1 hypothetical protein -
I6N99_RS02330 (489417) 489417..489983 - 567 WP_002892030.1 maltose O-acetyltransferase -
I6N99_RS02335 (490146) 490146..490364 - 219 WP_002892050.1 HHA domain-containing protein Toxin
I6N99_RS02340 (490391) 490391..490765 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6N99_RS02345 (491251) 491251..494397 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6N99_RS02350 (494420) 494420..495613 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T184038 WP_002892050.1 NZ_CP066143:c490364-490146 [Klebsiella pneumoniae U-0608239]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T184038 NZ_CP087294:c4367808-4367533 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTT
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT184038 WP_002892066.1 NZ_CP066143:c490765-490391 [Klebsiella pneumoniae U-0608239]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT184038 NZ_CP087294:c4367536-4367177 [Escherichia coli]
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTACTAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References