Detailed information of TA system TA184034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3374931..3375556
• Replicon: chromosome
• Accession: NZ_CP066140
• Organism: Morganella morganii strain FAM24670

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A0A2RCL2
• Locus tag: JC861_RS16240
• Protein ID: WP_024474604.1
• Coordinates: 3375353..3375556 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: JC861_RS16235
• Protein ID: WP_046893178.1
• Coordinates: 3374931..3375290 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC861_RS16225 (JC861_16220)	3369985..3371178	+	1194	WP_107678490.1	efflux RND transporter periplasmic adaptor subunit	-
JC861_RS16230 (JC861_16225)	3371193..3374369	+	3177	WP_107678491.1	efflux RND transporter permease subunit	-
JC861_RS16235 (JC861_16230)	3374931..3375290	+	360	WP_046893178.1	Hha toxicity modulator TomB	Antitoxin
JC861_RS16240 (JC861_16235)	3375353..3375556	+	204	WP_024474604.1	HHA domain-containing protein	Toxin
JC861_RS16250 (JC861_16245)	3376434..3377297	+	864	WP_054424719.1	acyl-CoA thioesterase II	-
JC861_RS16255 (JC861_16250)	3377359..3378648	-	1290	WP_107678658.1	ammonium transporter AmtB	-
JC861_RS16260 (JC861_16255)	3378668..3379006	-	339	WP_107678492.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-113)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8073.39 Da
• Isoelectric Point: 6.9770

>T184034 WP_024474604.1 NZ_CP066140:3375353-3375556 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T184034 NZ_CP087294:c3676747-3676340 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13840.57 Da
• Isoelectric Point: 4.2870

>AT184034 WP_046893178.1 NZ_CP066140:3374931-3375290 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Nucleotide

• Length: 360 bp

>AT184034 NZ_CP087294:c3676994-3676728 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0A2RCL2