Detailed information of TA system TA184031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1627..2101
• Replicon: plasmid unnamed1
• Accession: NZ_CP066139
• Organism: Morganella morganii strain FAM24671

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: JC830_RS20510
• Protein ID: WP_210647879.1
• Coordinates: 1835..2101 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: JC830_RS20505
• Protein ID: WP_210647878.1
• Coordinates: 1627..1851 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC830_RS20495 (JC830_20500)	11..958	+	948	WP_193797963.1	replication initiation protein	-
JC830_RS20500 (JC830_20505)	966..1379	+	414	WP_199557055.1	helix-turn-helix domain-containing protein	-
JC830_RS20505 (JC830_20510)	1627..1851	+	225	WP_210647878.1	DUF6290 family protein	Antitoxin
JC830_RS20510 (JC830_20515)	1835..2101	+	267	WP_210647879.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JC830_RS20515 (JC830_20520)	2139..2573	-	435	WP_218430340.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..10567	10567

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Relaxosome protein TraY (4-45)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10305.89 Da
• Isoelectric Point: 8.9101

>T184031 WP_210647879.1 NZ_CP066139:1835-2101 [Morganella morganii]
MAWTINYSDKALKSLRKMDKQNARRIVDFMDLRIAVLDDPRQSGKSLKGELGEFWRYRVGDYRILCEIRDAELIILAATI
GHRSDVYE

Nucleotide

• Length: 267 bp

>T184031 NZ_CP087294:c2750600-2750346 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8372.32 Da
• Isoelectric Point: 4.7778

>AT184031 WP_210647878.1 NZ_CP066139:1627-1851 [Morganella morganii]
MLAIRLSDDIESRLNSLAKQTGRTKTFYAREAILTHLEDLEDYYLSAETIAKIRSGDEQVHSSTDVRKSLGLDD

Nucleotide

• Length: 225 bp

>AT184031 NZ_CP087294:c2750848-2750597 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA