Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3370657..3371282 Replicon chromosome
Accession NZ_CP066138
Organism Morganella morganii strain FAM24671

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag JC830_RS16245 Protein ID WP_024474604.1
Coordinates 3371079..3371282 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JC830_RS16240 Protein ID WP_046893178.1
Coordinates 3370657..3371016 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC830_RS16230 (JC830_16235) 3365710..3366903 + 1194 WP_107678490.1 efflux RND transporter periplasmic adaptor subunit -
JC830_RS16235 (JC830_16240) 3366918..3370095 + 3178 Protein_3190 efflux RND transporter permease subunit -
JC830_RS16240 (JC830_16245) 3370657..3371016 + 360 WP_046893178.1 Hha toxicity modulator TomB Antitoxin
JC830_RS16245 (JC830_16250) 3371079..3371282 + 204 WP_024474604.1 HHA domain-containing protein Toxin
JC830_RS16255 (JC830_16260) 3372160..3373023 + 864 WP_054424719.1 acyl-CoA thioesterase II -
JC830_RS16260 (JC830_16265) 3373085..3374375 - 1291 Protein_3194 ammonium transporter AmtB -
JC830_RS16265 (JC830_16270) 3374395..3374733 - 339 WP_107678492.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T184030 WP_024474604.1 NZ_CP066138:3371079-3371282 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T184030 NZ_CP087294:c2540386-2540284 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13840.57 Da        Isoelectric Point: 4.2870

>AT184030 WP_046893178.1 NZ_CP066138:3370657-3371016 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT184030 NZ_CP087294:2540246-2540514 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure

References