Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3451435..3452060 Replicon chromosome
Accession NZ_CP066137
Organism Morganella morganii strain FAM24672

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag JC827_RS16630 Protein ID WP_024474604.1
Coordinates 3451857..3452060 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JC827_RS16625 Protein ID WP_046893178.1
Coordinates 3451435..3451794 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC827_RS16615 (JC827_16605) 3446489..3447682 + 1194 WP_107678490.1 efflux RND transporter periplasmic adaptor subunit -
JC827_RS16620 (JC827_16610) 3447697..3450873 + 3177 WP_107678491.1 efflux RND transporter permease subunit -
JC827_RS16625 (JC827_16615) 3451435..3451794 + 360 WP_046893178.1 Hha toxicity modulator TomB Antitoxin
JC827_RS16630 (JC827_16620) 3451857..3452060 + 204 WP_024474604.1 HHA domain-containing protein Toxin
JC827_RS16640 (JC827_16630) 3452938..3453801 + 864 WP_054424719.1 acyl-CoA thioesterase II -
JC827_RS16645 (JC827_16635) 3453863..3455075 - 1213 Protein_3273 ammonium transporter AmtB -
JC827_RS16650 (JC827_16640) 3455174..3455512 - 339 WP_107678492.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T184027 WP_024474604.1 NZ_CP066137:3451857-3452060 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T184027 NZ_CP087294:c1889302-1889195 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13840.57 Da        Isoelectric Point: 4.2870

>AT184027 WP_046893178.1 NZ_CP066137:3451435-3451794 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT184027 NZ_CP087294:1889355-1889416 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure

References