Detailed information of TA system TA184024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 50796..51349
• Replicon: plasmid unnamed1
• Accession: NZ_CP066134
• Organism: Morganella morganii strain FAM24675

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: JC826_RS20310
• Protein ID: WP_218453999.1
• Coordinates: 51035..51349 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: JC826_RS20305
• Protein ID: WP_036419383.1
• Coordinates: 50796..51032 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC826_RS20275 (JC826_20280)	47307..47984	+	678	Protein_51	IS1 family transposase	-
JC826_RS20280 (JC826_20285)	48105..48841	-	737	Protein_52	IS6 family transposase	-
JC826_RS20290 (JC826_20295)	49201..49491	-	291	WP_218455733.1	NadS family protein	-
JC826_RS20295 (JC826_20300)	49491..49820	-	330	WP_096862169.1	type II toxin-antitoxin system RelE/ParE family toxin	-
JC826_RS20300 (JC826_20305)	50037..50660	+	624	WP_218453998.1	recombinase family protein	-
JC826_RS20305 (JC826_20310)	50796..51032	+	237	WP_036419383.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
JC826_RS20310 (JC826_20315)	51035..51349	+	315	WP_218453999.1	CcdB family protein	Toxin
JC826_RS20315 (JC826_20320)	51382..51948	+	567	WP_218454000.1	ProQ/FINO family protein	-
JC826_RS20320 (JC826_20325)	52276..53256	-	981	WP_000019445.1	IS5-like element ISKpn26 family transposase	-
JC826_RS20325 (JC826_20330)	53428..53659	-	232	Protein_60	plasmid partition protein ParG	-
JC826_RS20330 (JC826_20335)	53711..54331	-	621	WP_000864788.1	ParA family protein	-
JC826_RS20335 (JC826_20340)	54626..55273	+	648	WP_024262784.1	recombinase family protein	-
JC826_RS20340 (JC826_20345)	55450..56181	-	732	WP_045282355.1	HNH endonuclease signature motif containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..65233	65233
	-	inside	IScluster/Tn	-	-	39999..59726	19727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11656.65 Da
• Isoelectric Point: 6.9742

>T184024 WP_218453999.1 NZ_CP066134:51035-51349 [Morganella morganii]
MQFTVYNNTGKSAVYPMLLDVTSDIIGQLNRRIVIPLLPVENYPPGARPKRLVPLIRLTDDKEYAVMTHEMASIPARSLG
IVFCDASLYRTEIKAAIDFLFDGV

Nucleotide

• Length: 315 bp

>T184024 NZ_CP087294:1141280-1141582 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8976.09 Da
• Isoelectric Point: 6.4639

>AT184024 WP_036419383.1 NZ_CP066134:50796-51032 [Morganella morganii]
MAIKQRATKSVTMTVERVLLSRAREAGINLSATLTAALDAELRRYEAKKWQEENSEALEALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT184024 NZ_CP087294:1141618-1141959 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG