Detailed information of TA system TA184023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3325245..3325870
• Replicon: chromosome
• Accession: NZ_CP066133
• Organism: Morganella morganii strain FAM24675

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A0A2RCL2
• Locus tag: JC826_RS15860
• Protein ID: WP_024474604.1
• Coordinates: 3325667..3325870 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: JC826_RS15855
• Protein ID: WP_046893178.1
• Coordinates: 3325245..3325604 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC826_RS15845 (JC826_15850)	3320299..3321492	+	1194	WP_107678490.1	efflux RND transporter periplasmic adaptor subunit	-
JC826_RS15850 (JC826_15855)	3321507..3324683	+	3177	WP_107678491.1	efflux RND transporter permease subunit	-
JC826_RS15855 (JC826_15860)	3325245..3325604	+	360	WP_046893178.1	Hha toxicity modulator TomB	Antitoxin
JC826_RS15860 (JC826_15865)	3325667..3325870	+	204	WP_024474604.1	HHA domain-containing protein	Toxin
JC826_RS15870 (JC826_15875)	3326748..3327611	+	864	WP_054424719.1	acyl-CoA thioesterase II	-
JC826_RS15875 (JC826_15880)	3327673..3328962	-	1290	WP_107678658.1	ammonium transporter AmtB	-
JC826_RS15880 (JC826_15885)	3328982..3329320	-	339	WP_107678492.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-113)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8073.39 Da
• Isoelectric Point: 6.9770

>T184023 WP_024474604.1 NZ_CP066133:3325667-3325870 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T184023 NZ_CP087294:c1113528-1113310 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13840.57 Da
• Isoelectric Point: 4.2870

>AT184023 WP_046893178.1 NZ_CP066133:3325245-3325604 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Nucleotide

• Length: 360 bp

>AT184023 NZ_CP087294:c1113928-1113554 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A0A2RCL2