Detailed information of TA system TA184020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3226788..3227413
• Replicon: chromosome
• Accession: NZ_CP066132
• Organism: Morganella morganii strain FAM24676

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A0A2RCL2
• Locus tag: JC825_RS15300
• Protein ID: WP_024474604.1
• Coordinates: 3227210..3227413 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: JC825_RS15295
• Protein ID: WP_046893178.1
• Coordinates: 3226788..3227147 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC825_RS15285 (JC825_15290)	3221842..3223035	+	1194	WP_166708462.1	efflux RND transporter periplasmic adaptor subunit	-
JC825_RS15290 (JC825_15295)	3223050..3226226	+	3177	WP_107678491.1	efflux RND transporter permease subunit	-
JC825_RS15295 (JC825_15300)	3226788..3227147	+	360	WP_046893178.1	Hha toxicity modulator TomB	Antitoxin
JC825_RS15300 (JC825_15305)	3227210..3227413	+	204	WP_024474604.1	HHA domain-containing protein	Toxin
JC825_RS15310 (JC825_15315)	3228302..3229165	+	864	WP_218454529.1	acyl-CoA thioesterase II	-
JC825_RS15315 (JC825_15320)	3229227..3230516	-	1290	WP_218455652.1	ammonium transporter AmtB	-
JC825_RS15320 (JC825_15325)	3230536..3230874	-	339	WP_218454530.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-113)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8073.39 Da
• Isoelectric Point: 6.9770

>T184020 WP_024474604.1 NZ_CP066132:3227210-3227413 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T184020 NZ_CP087294:284725-284898 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13840.57 Da
• Isoelectric Point: 4.2870

>AT184020 WP_046893178.1 NZ_CP066132:3226788-3227147 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Nucleotide

• Length: 360 bp

>AT184020 NZ_CP087294:284401-284697 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAGTTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0A2RCL2