Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 58318..58871 Replicon plasmid unnamed1
Accession NZ_CP066131
Organism Morganella morganii strain FAM24678

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag JC792_RS20100 Protein ID WP_218453999.1
Coordinates 58557..58871 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag JC792_RS20095 Protein ID WP_036419383.1
Coordinates 58318..58554 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC792_RS20065 (JC792_20060) 54828..55505 + 678 Protein_53 IS1 family transposase -
JC792_RS20070 (JC792_20065) 55626..56362 - 737 Protein_54 IS6 family transposase -
JC792_RS20080 (JC792_20075) 56675..57013 - 339 WP_218454005.1 NadS family protein -
JC792_RS20085 (JC792_20080) 57013..57342 - 330 WP_096862169.1 type II toxin-antitoxin system RelE/ParE family toxin -
JC792_RS20090 (JC792_20085) 57559..58182 + 624 WP_218453998.1 recombinase family protein -
JC792_RS20095 (JC792_20090) 58318..58554 + 237 WP_036419383.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JC792_RS20100 (JC792_20095) 58557..58871 + 315 WP_218453999.1 CcdB family protein Toxin
JC792_RS20105 (JC792_20100) 58904..59470 + 567 WP_218454000.1 ProQ/FINO family protein -
JC792_RS20110 (JC792_20105) 59798..60778 - 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
JC792_RS20115 (JC792_20110) 60950..61181 - 232 Protein_62 plasmid partition protein ParG -
JC792_RS20120 (JC792_20115) 61233..61853 - 621 WP_000864788.1 ParA family protein -
JC792_RS20125 (JC792_20120) 62148..62795 + 648 WP_024262784.1 recombinase family protein -
JC792_RS20130 (JC792_20125) 62972..63703 - 732 WP_045282355.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..72755 72755
- inside IScluster/Tn - - 39850..67248 27398


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11656.65 Da        Isoelectric Point: 6.9742

>T184016 WP_218453999.1 NZ_CP066131:58557-58871 [Morganella morganii]
MQFTVYNNTGKSAVYPMLLDVTSDIIGQLNRRIVIPLLPVENYPPGARPKRLVPLIRLTDDKEYAVMTHEMASIPARSLG
IVFCDASLYRTEIKAAIDFLFDGV

Download         Length: 315 bp

>T184016 NZ_CP087291:c56278-56003 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCACCAGAACGGTGCAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8976.09 Da        Isoelectric Point: 6.4639

>AT184016 WP_036419383.1 NZ_CP066131:58318-58554 [Morganella morganii]
MAIKQRATKSVTMTVERVLLSRAREAGINLSATLTAALDAELRRYEAKKWQEENSEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT184016 NZ_CP087291:c56562-56278 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCAATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGAAATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References