Detailed information of TA system TA184012

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3782505..3784120
• Replicon: chromosome
• Accession: NZ_CP066129
• Organism: Morganella morganii strain FAM24679

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JC793_RS17675
• Protein ID: WP_218426883.1
• Coordinates: 3782505..3783830 (-)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JC793_RS17680
• Protein ID: WP_218426884.1
• Coordinates: 3783833..3784120 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC793_RS17655 (JC793_17655)	3779160..3780032	+	873	WP_218426877.1	HNH endonuclease	-
JC793_RS17665 (JC793_17665)	3780607..3781782	-	1176	WP_247717284.1	reverse transcriptase family protein	-
JC793_RS17670 (JC793_17670)	3781819..3782025	-	207	WP_218426881.1	hypothetical protein	-
JC793_RS17675 (JC793_17675)	3782505..3783830	-	1326	WP_218426883.1	type II toxin-antitoxin system HipA family toxin	Toxin
JC793_RS17680 (JC793_17680)	3783833..3784120	-	288	WP_218426884.1	helix-turn-helix transcriptional regulator	Antitoxin
JC793_RS17685 (JC793_17685)	3784355..3785677	+	1323	WP_218426886.1	hypothetical protein	-
JC793_RS17690 (JC793_17690)	3786482..3787360	+	879	WP_218426888.1	integrase domain-containing protein	-
JC793_RS17695 (JC793_17695)	3787363..3787563	+	201	WP_218428494.1	AlpA family transcriptional regulator	-
JC793_RS17700 (JC793_17700)	3787761..3787937	+	177	WP_218426890.1	hypothetical protein	-
JC793_RS19685	3787993..3788772	+	780	Protein_3480	primase-helicase zinc-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3775354..3791535	16181

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 50288.38 Da
• Isoelectric Point: 5.8814

>T184012 WP_218426883.1 NZ_CP066129:c3783830-3782505 [Morganella morganii]
MSRTQQRLAIWMNGIRVGFWEKIRGEDRLHYLPEWVADEQGRQLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEDIRRRL
AMRYRAESLEPFDLLAELGRDCVGAIQLLHPDDEPADLFSVNYRPLSEADIAAILRNTTTSIPGRHSDDEELRLSIAGAQ
EKTALLWNDGQWCLPEGNTPTTHIFKLPLGLVGNMKADMSTSVENEWLCSLILEHYGIPVAKTQIAQFEDQKVLIVDRFD
RRWSTDRQWIVRLPQEDMCQALGVSPLRKYQADGGPGITDIMGILSHSEQAEQDRETFFKAQIIFWLMAATDGHAKNFSI
SMEPQNRYRLTPLYDVLSAWPLIGNGNNQIAWQKCKLAMAVRGSSNYYLMSKIQRRHWIKHGETVGFEKQQVEAMLDDII
GRTPEVIERVSALLPEGFPVGVAERVFGGMRKLNPVLTRGV

Nucleotide

• Length: 1326 bp

>T184012 NZ_CP087290:4749970-4750146 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTAAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10611.24 Da
• Isoelectric Point: 10.3759

>AT184012 WP_218426884.1 NZ_CP066129:c3784120-3783833 [Morganella morganii]
MNTAYPLKTLNQLRPLLVGFRKANGMTQKDVSEKLGVTQQTYARLEANPASASIERLFKVFTVLGVEMVLSAGQFSVIRE
SAEIPDNSPARREKW

Nucleotide

• Length: 288 bp

>AT184012 NZ_CP087290:4750190-4750606 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACTCCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTGAC
GCAGGGAGAAACTGTTGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCTTATTTAACTTGCACCATGCTACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA