Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3264106..3264731 Replicon chromosome
Accession NZ_CP066129
Organism Morganella morganii strain FAM24679

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag JC793_RS15445 Protein ID WP_024474604.1
Coordinates 3264528..3264731 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JC793_RS15440 Protein ID WP_046893178.1
Coordinates 3264106..3264465 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC793_RS15430 (JC793_15430) 3259160..3260353 + 1194 WP_166708462.1 efflux RND transporter periplasmic adaptor subunit -
JC793_RS15435 (JC793_15435) 3260368..3263544 + 3177 WP_218426586.1 efflux RND transporter permease subunit -
JC793_RS15440 (JC793_15440) 3264106..3264465 + 360 WP_046893178.1 Hha toxicity modulator TomB Antitoxin
JC793_RS15445 (JC793_15445) 3264528..3264731 + 204 WP_024474604.1 HHA domain-containing protein Toxin
JC793_RS15455 (JC793_15455) 3265620..3266483 + 864 WP_166708464.1 acyl-CoA thioesterase II -
JC793_RS15460 (JC793_15460) 3266544..3267833 - 1290 WP_218428470.1 ammonium transporter AmtB -
JC793_RS15465 (JC793_15465) 3267853..3268191 - 339 WP_218426587.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T184011 WP_024474604.1 NZ_CP066129:3264528-3264731 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T184011 NZ_CP087290:c4651837-4651643 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGTCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAACGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13840.57 Da        Isoelectric Point: 4.2870

>AT184011 WP_046893178.1 NZ_CP066129:3264106-3264465 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT184011 NZ_CP087290:4651466-4651644 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure

References