Detailed information of TA system TA184007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3304920..3305545
• Replicon: chromosome
• Accession: NZ_CP066127
• Organism: Morganella morganii strain FAM24685

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A0A2RCL2
• Locus tag: JA116_RS15880
• Protein ID: WP_024474604.1
• Coordinates: 3305342..3305545 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: JA116_RS15875
• Protein ID: WP_046893178.1
• Coordinates: 3304920..3305279 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JA116_RS15865 (JA116_15865)	3299974..3301167	+	1194	WP_107678490.1	efflux RND transporter periplasmic adaptor subunit	-
JA116_RS15870 (JA116_15870)	3301182..3304358	+	3177	WP_107678491.1	efflux RND transporter permease subunit	-
JA116_RS15875 (JA116_15875)	3304920..3305279	+	360	WP_046893178.1	Hha toxicity modulator TomB	Antitoxin
JA116_RS15880 (JA116_15880)	3305342..3305545	+	204	WP_024474604.1	HHA domain-containing protein	Toxin
JA116_RS15890 (JA116_15890)	3306423..3307286	+	864	WP_054424719.1	acyl-CoA thioesterase II	-
JA116_RS15895 (JA116_15895)	3307348..3308638	-	1291	Protein_3125	ammonium transporter AmtB	-
JA116_RS15900 (JA116_15900)	3308658..3308996	-	339	WP_107678492.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-113)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8073.39 Da
• Isoelectric Point: 6.9770

>T184007 WP_024474604.1 NZ_CP066127:3305342-3305545 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T184007 NZ_CP087290:3743539-3743841 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13840.57 Da
• Isoelectric Point: 4.2870

>AT184007 WP_046893178.1 NZ_CP066127:3304920-3305279 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNFWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Nucleotide

• Length: 360 bp

>AT184007 NZ_CP087290:3743877-3744218 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Toxin

• AlphaFold DB: A0A0A2RCL2