Detailed information of TA system TA184004

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4803203..4803835
• Replicon: chromosome
• Accession: NZ_CP066126
• Organism: Chromobacterium rhizoryzae strain 32279

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JC616_RS21950
• Protein ID: WP_227105451.1
• Coordinates: 4803419..4803835 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2T5NW37
• Locus tag: JC616_RS21945
• Protein ID: WP_019103136.1
• Coordinates: 4803203..4803415 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC616_RS21935	4798830..4799963	+	1134	WP_227105447.1	efflux RND transporter periplasmic adaptor subunit	-
JC616_RS21940	4799963..4803049	+	3087	WP_227105449.1	efflux RND transporter permease subunit	-
JC616_RS21945	4803203..4803415	+	213	WP_019103136.1	hypothetical protein	Antitoxin
JC616_RS21950	4803419..4803835	+	417	WP_227105451.1	type II toxin-antitoxin system VapC family toxin	Toxin
JC616_RS21955	4803841..4804338	-	498	WP_227105452.1	CNP1-like family protein	-
JC616_RS21960	4804353..4805132	-	780	WP_107800874.1	NRDE family protein	-
JC616_RS21965	4805322..4805552	+	231	WP_043589636.1	sulfurtransferase TusA family protein	-
JC616_RS21970	4805574..4805750	-	177	WP_227105454.1	hypothetical protein	-
JC616_RS21975	4805749..4806786	+	1038	WP_227105456.1	dihydroorotase	-
JC616_RS21980	4806901..4807242	-	342	WP_107800876.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
JC616_RS21985	4807551..4808300	+	750	WP_048413068.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15088.20 Da
• Isoelectric Point: 6.7178

>T184004 WP_227105451.1 NZ_CP066126:4803419-4803835 [Chromobacterium rhizoryzae]
VYLVDTNIVSEARKGGKANAGVLAFWRSADTDSLYLSAISVGEIRRGIENLKHRGDLKQAGLLEQWLDTITQEFSQRILN
FDADCAQVWGKLMSPHPQNAVDKQIAAIALIHDLTIVTRNSGDFAGTGVKLLNPFAPI

Nucleotide

• Length: 417 bp

>T184004 NZ_CP087290:c2842263-2841886 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7840.84 Da
• Isoelectric Point: 6.4684

>AT184004 WP_019103136.1 NZ_CP066126:4803203-4803415 [Chromobacterium rhizoryzae]
MANLIVRNIDDEVAAELKRRAAAHGVSAEAEHRRILRSALLAQPKRRSFAEVLANMPDVGEDADFERSRE

Nucleotide

• Length: 213 bp

>AT184004 NZ_CP087290:c2842684-2842310 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: A0A2T5NW37