Detailed information of TA system TA184002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1499483..1500085
• Replicon: chromosome
• Accession: NZ_CP066126
• Organism: Chromobacterium rhizoryzae strain 32279

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0J6MTI0
• Locus tag: JC616_RS06915
• Protein ID: WP_043634155.1
• Coordinates: 1499483..1499665 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JC616_RS06920
• Protein ID: WP_081551195.1
• Coordinates: 1499675..1500085 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC616_RS06895	1494956..1495669	-	714	WP_205465673.1	ABC transporter permease subunit	-
JC616_RS06900	1495710..1496480	-	771	WP_227107424.1	transporter substrate-binding domain-containing protein	-
JC616_RS06905	1496499..1497248	-	750	WP_227108563.1	ATP-binding cassette domain-containing protein	-
JC616_RS06910	1497781..1499199	+	1419	WP_227107426.1	sigma 54-interacting transcriptional regulator	-
JC616_RS06915	1499483..1499665	+	183	WP_043634155.1	type II toxin-antitoxin system HicA family toxin	Toxin
JC616_RS06920	1499675..1500085	+	411	WP_081551195.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JC616_RS06925	1500257..1501195	-	939	WP_227107428.1	PDR/VanB family oxidoreductase	-
JC616_RS06930	1501211..1502356	-	1146	WP_227107430.1	ring-hydroxylating oxygenase subunit alpha	-
JC616_RS06935	1502677..1503618	+	942	WP_227107431.1	GlxA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6578.73 Da
• Isoelectric Point: 10.7364

>T184002 WP_043634155.1 NZ_CP066126:1499483-1499665 [Chromobacterium rhizoryzae]
VTSKEVISMIEADGWYLVAAKGSHQQFKHPIKTGRVTVPHPKKDIPIGTLNSIKKQAGLK

Nucleotide

• Length: 183 bp

>T184002 NZ_CP087290:2696241-2696627 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14881.87 Da
• Isoelectric Point: 4.6312

>AT184002 WP_081551195.1 NZ_CP066126:1499675-1500085 [Chromobacterium rhizoryzae]
MYYPIAVEPGDDQHAYGVIVPDLPGCFSAGDTLDEAIRNAREAIELHLEGLVEDLDVIPLASSAQAHVGKSEFAGHLWAL
VDVDITRYLGKATKINVTLPANLLHRIDEYVASHPEYDSRSGFLAKTALEKLLCRP

Nucleotide

• Length: 411 bp

>AT184002 NZ_CP087290:2695702-2696211 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA

Structures

Toxin

• AlphaFold DB: A0A0J6MTI0