Detailed information of TA system TA184001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4989690..4991263
• Replicon: chromosome
• Accession: NZ_CP066125
• Organism: Aeromonas veronii strain 32286

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: JC622_RS23395
• Protein ID: WP_227095587.1
• Coordinates: 4989690..4991009 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3Q8DTG9
• Locus tag: JC622_RS23400
• Protein ID: WP_042047685.1
• Coordinates: 4991009..4991263 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC622_RS23380	4985609..4986373	+	765	WP_227095585.1	ATP-binding cassette domain-containing protein	-
JC622_RS23385	4986408..4987292	+	885	WP_227096682.1	ABC transporter substrate-binding protein	-
JC622_RS23390	4987289..4989268	+	1980	WP_227095586.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
JC622_RS23395	4989690..4991009	-	1320	WP_227095587.1	type II toxin-antitoxin system HipA family toxin	Toxin
JC622_RS23400	4991009..4991263	-	255	WP_042047685.1	helix-turn-helix domain-containing protein	Antitoxin
JC622_RS23405	4991433..4991861	-	429	WP_075112289.1	DUF86 domain-containing protein	-
JC622_RS23410	4991854..4992303	-	450	WP_227095588.1	nucleotidyltransferase domain-containing protein	-
JC622_RS23415	4992750..4992965	+	216	Protein_4534	recombinase family protein	-
JC622_RS23420	4993008..4994206	-	1199	Protein_4535	IS3 family transposase	-
JC622_RS23425	4994349..4994705	+	357	WP_227095589.1	helix-turn-helix domain-containing protein	-
JC622_RS23430	4994702..4995025	-	324	WP_103251847.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49372.35 Da
• Isoelectric Point: 7.0148

>T184001 WP_227095587.1 NZ_CP066125:c4991009-4989690 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQSGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDGELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T184001 NZ_CP087290:2475608-2475919 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT184001 WP_042047685.1 NZ_CP066125:c4991263-4991009 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT184001 NZ_CP087290:2475920-2476210 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A3Q8DTG9