183999

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2659382..2660075 Replicon chromosome
Accession NZ_CP066125
Organism Aeromonas veronii strain 32286

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag JC622_RS12325 Protein ID WP_000182276.1
Coordinates 2659382..2659738 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag JC622_RS12330 Protein ID WP_001172026.1
Coordinates 2659740..2660075 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC622_RS12315 2655575..2658604 - 3030 WP_032432545.1 Tn3 family transposase -
JC622_RS12320 2658588..2659190 - 603 WP_010465829.1 recombinase family protein -
JC622_RS12325 2659382..2659738 + 357 WP_000182276.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC622_RS12330 2659740..2660075 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
JC622_RS12335 2660090..2660425 + 336 WP_000741275.1 hypothetical protein -
JC622_RS12340 2660449..2660775 + 327 WP_000091614.1 hypothetical protein -
JC622_RS12345 2660772..2661152 + 381 WP_001054412.1 hypothetical protein -
JC622_RS12355 2661309..2661660 + 352 Protein_2396 DUF3391 domain-containing protein -
JC622_RS12360 2661685..2662548 + 864 WP_258313396.1 HD-GYP domain-containing protein -
JC622_RS12365 2662717..2662947 + 231 Protein_2398 IS3 family transposase -
JC622_RS12370 2662977..2663188 - 212 Protein_2399 IS110 family transposase -
JC622_RS12375 2663380..2664516 - 1137 WP_041204891.1 ISAs1-like element ISAeme1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2650774..2693146 42372
- inside IScluster/Tn - - 2650774..2676955 26181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12912.93 Da        Isoelectric Point: 8.9018

>T183999 WP_000182276.1 NZ_CP066125:2659382-2659738 [Aeromonas veronii]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL

Download         Length: 357 bp

>T183999 NZ_CP087290:c2063449-2063342 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT183999 WP_001172026.1 NZ_CP066125:2659740-2660075 [Aeromonas veronii]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT183999 NZ_CP087290:2063498-2063564 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References