Detailed information of TA system TA183998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 1490676..1491253
• Replicon: chromosome
• Accession: NZ_CP066125
• Organism: Aeromonas veronii strain 32286

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: JC622_RS07115
• Protein ID: WP_182785848.1
• Coordinates: 1490676..1491074 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: JC622_RS07120
• Protein ID: WP_182969248.1
• Coordinates: 1491074..1491253 (-)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JC622_RS07115	1490676..1491074	-	399	WP_182785848.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
JC622_RS07120	1491074..1491253	-	180	WP_182969248.1	hypothetical protein	Antitoxin
JC622_RS07125	1491587..1492351	-	765	WP_162726212.1	hypothetical protein	-
JC622_RS07130	1492423..1492731	-	309	WP_109421865.1	Arc family DNA-binding protein	-
JC622_RS07135	1492911..1493078	+	168	WP_201984706.1	Arc family DNA-binding protein	-
JC622_RS07140	1493071..1493220	+	150	WP_162726211.1	Arc family DNA-binding protein	-
JC622_RS07145	1493302..1494120	+	819	WP_227096163.1	KilA-N domain-containing protein	-
JC622_RS07150	1494117..1494977	+	861	WP_227096164.1	BRO family protein	-
JC622_RS07155	1494974..1495450	+	477	WP_043162698.1	hypothetical protein	-
JC622_RS23555	1495447..1495578	+	132	WP_265324680.1	hypothetical protein	-
JC622_RS23560	1495706..1495828	+	123	WP_258039730.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1437442..1494977	57535

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (36-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14492.52 Da
• Isoelectric Point: 4.1179

>T183998 WP_182785848.1 NZ_CP066125:c1491074-1490676 [Aeromonas veronii]
MDIIQFPPARVLEINHYILGASPGHQGPASIALLEGALGRIDNAIAYNGLNDVFLIAAKYAMAIGTAHAFSDANKRTGLA
VCLEYLSLNDFEIERDNEKLADAMVDLVLGELPEEWFADILYALWLEEQKTS

Nucleotide

• Length: 399 bp

>T183998 NZ_CP087290:c2062966-2062859 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6774.79 Da
• Isoelectric Point: 10.1555

>AT183998 WP_182969248.1 NZ_CP066125:c1491253-1491074 [Aeromonas veronii]
MKDNSVSNKYGLPQVQNRPQIKAEKNLCLNGEEGRQIIKSETKLTLKTHEKTFTRLADM

Nucleotide

• Length: 180 bp

>AT183998 NZ_CP087290:2063023-2063081 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC