Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3090213..3090802 Replicon chromosome
Accession NZ_CP066124
Organism Acinetobacter pittii strain 32292

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag JC624_RS14805 Protein ID WP_227061851.1
Coordinates 3090213..3090515 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JC624_RS14810 Protein ID WP_227061854.1
Coordinates 3090512..3090802 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC624_RS14765 3085991..3086185 - 195 WP_000084541.1 hypothetical protein -
JC624_RS14770 3086310..3086864 - 555 WP_227061841.1 lysozyme -
JC624_RS14775 3086861..3087256 - 396 WP_227061842.1 hypothetical protein -
JC624_RS14780 3087357..3087608 - 252 WP_227061844.1 hypothetical protein -
JC624_RS14785 3087758..3088507 + 750 WP_227061845.1 serine protease -
JC624_RS14790 3088536..3089468 - 933 WP_227063877.1 KilA-N domain-containing protein -
JC624_RS14795 3089555..3089716 - 162 WP_227061847.1 ribbon-helix-helix domain-containing protein -
JC624_RS14800 3089840..3090124 + 285 WP_227061849.1 Arc family DNA-binding protein -
JC624_RS14805 3090213..3090515 + 303 WP_227061851.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC624_RS14810 3090512..3090802 + 291 WP_227061854.1 putative addiction module antidote protein Antitoxin
JC624_RS14815 3090832..3092919 - 2088 WP_227061856.1 hypothetical protein -
JC624_RS14820 3092957..3093772 - 816 WP_227061857.1 hypothetical protein -
JC624_RS14825 3093888..3095615 - 1728 WP_227061859.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3076938..3131443 54505


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-95)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11421.76 Da        Isoelectric Point: 4.4821

>T183997 WP_227061851.1 NZ_CP066124:3090213-3090515 [Acinetobacter pittii]
MYEIKTTETFDEWFDSLRDTQGKARINARLRRVELGNFGDAEPVGENVSELRFFFGPGYRIYFIQNGDEIIVLLAGGDKS
SQQKDIDKAIELAKEIRGES

Download         Length: 303 bp

>T183997 NZ_CP087290:c1981909-1981634 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTT
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10690.20 Da        Isoelectric Point: 6.2257

>AT183997 WP_227061854.1 NZ_CP066124:3090512-3090802 [Acinetobacter pittii]
MTIKLKKWDIQDHLKTEEERQAYLEAALEEASDDPLYIAHVLGDIAKSYGMTKLAQETGLTREGLYKSFGKQGNPSFVTV
SKVASAMGLKLTFEHA

Download         Length: 291 bp

>AT183997 NZ_CP087290:c1981637-1981278 [Escherichia coli]
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTACTAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References