Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1961022..1962658 Replicon chromosome
Accession NZ_CP066124
Organism Acinetobacter pittii strain 32292

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JC624_RS09385 Protein ID WP_227063705.1
Coordinates 1961022..1962353 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JC624_RS09390 Protein ID WP_227063707.1
Coordinates 1962350..1962658 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC624_RS09370 1957603..1958931 + 1329 WP_227063699.1 TolC family protein -
JC624_RS09375 1958924..1960087 + 1164 WP_227063700.1 hypothetical protein -
JC624_RS09380 1960287..1960727 - 441 WP_227063703.1 HD domain-containing protein -
JC624_RS09385 1961022..1962353 + 1332 WP_227063705.1 HipA domain-containing protein Toxin
JC624_RS09390 1962350..1962658 + 309 WP_227063707.1 helix-turn-helix domain-containing protein Antitoxin
JC624_RS09395 1962864..1963295 + 432 WP_227063709.1 hypothetical protein -
JC624_RS09400 1963388..1963606 - 219 WP_227063711.1 Txe/YoeB family addiction module toxin -
JC624_RS09405 1963563..1964021 - 459 WP_227063713.1 hypothetical protein -
JC624_RS09410 1964147..1965001 - 855 WP_227063715.1 hypothetical protein -
JC624_RS09415 1965059..1965865 - 807 WP_227063718.1 hypothetical protein -
JC624_RS09420 1965989..1966384 - 396 WP_227063722.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-82)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51129.99 Da        Isoelectric Point: 4.7487

>T183996 WP_227063705.1 NZ_CP066124:1961022-1962353 [Acinetobacter pittii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQQVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWRDQSWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCELLTSIDSDFDASQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKSVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T183996 NZ_CP087290:c1954413-1954036 [Escherichia coli]
ATGACCATTCAGTTTATCTCAGCGGAGGAGATAATTTATTTCCACGATAAATTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTATGAGTATGAAGGCGTTTCTGATCTTT
GGTTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATCTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCATCATACTTGCTGCAAACCCAGAGTTTGTAGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACGCGGTACCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11644.57 Da        Isoelectric Point: 9.9701

>AT183996 WP_227063707.1 NZ_CP066124:1962350-1962658 [Acinetobacter pittii]
MNIKNQTEDRQQVLIDLYKQYLLSQITLGQLLSYLRKNVLGLSQEQYATLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVNKIIKPNE

Download         Length: 309 bp

>AT183996 NZ_CP087290:c1954631-1954410 [Escherichia coli]
ATGCATACCATGAACTACAGCGAAGCGCGGCAGAACCTTGCATTAGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCAGCTGTGATTATCAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CAGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTAAGGAGTTAGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References