Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 462496..463149 Replicon chromosome
Accession NZ_CP066124
Organism Acinetobacter pittii strain 32292

Toxin (Protein)


Gene name cptA Uniprot ID F0KQ02
Locus tag JC624_RS02290 Protein ID WP_014207739.1
Coordinates 462760..463149 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag JC624_RS02285 Protein ID WP_002117064.1
Coordinates 462496..462753 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC624_RS02265 458010..459017 + 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -
JC624_RS02270 459036..459413 + 378 WP_002049717.1 50S ribosomal protein L17 -
JC624_RS02275 459595..461085 + 1491 WP_227062679.1 NAD(P)/FAD-dependent oxidoreductase -
JC624_RS02280 461135..462307 - 1173 WP_017400434.1 acyl-CoA dehydrogenase family protein -
JC624_RS02285 462496..462753 + 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
JC624_RS02290 462760..463149 + 390 WP_014207739.1 hypothetical protein Toxin
JC624_RS02295 463920..465008 + 1089 WP_017400432.1 hypothetical protein -
JC624_RS02300 465093..465668 + 576 WP_068563847.1 rhombosortase -
JC624_RS02305 465848..468043 + 2196 WP_063097833.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15549.66 Da        Isoelectric Point: 8.7390

>T183995 WP_014207739.1 NZ_CP066124:462760-463149 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVTYFSKKEI
YRAEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T183995 NZ_CP087290:1647055-1647519 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT183995 WP_002117064.1 NZ_CP066124:462496-462753 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT183995 NZ_CP087290:1646720-1647055 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C2PTH0

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References