Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 4467637..4468190 Replicon chromosome
Accession NZ_CP066123
Organism Pseudomonas sp. MPFS

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag I9018_RS20460 Protein ID WP_277398076.1
Coordinates 4467637..4467930 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I9018_RS20465 Protein ID WP_241107364.1
Coordinates 4467918..4468190 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9018_RS20435 (I9018_20370) 4463517..4464836 + 1320 WP_241107361.1 MFS transporter -
I9018_RS20440 (I9018_20375) 4464969..4465118 - 150 WP_241110218.1 hypothetical protein -
I9018_RS20445 (I9018_20380) 4465193..4465879 - 687 WP_068582395.1 hypothetical protein -
I9018_RS20450 (I9018_20385) 4465879..4466847 - 969 WP_241107362.1 hypothetical protein -
I9018_RS20455 (I9018_20390) 4467167..4467559 + 393 WP_241107363.1 DUF3077 domain-containing protein -
I9018_RS20460 (I9018_20395) 4467637..4467930 - 294 WP_277398076.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I9018_RS20465 (I9018_20400) 4467918..4468190 - 273 WP_241107364.1 CopG family ribbon-helix-helix protein Antitoxin
I9018_RS20470 (I9018_20405) 4468552..4470585 - 2034 WP_241107365.1 LTA synthase family protein -
I9018_RS20475 (I9018_20410) 4470635..4471246 - 612 WP_241107366.1 hypothetical protein -
I9018_RS20480 (I9018_20415) 4471246..4472538 - 1293 WP_241107367.1 sialidase family protein -
I9018_RS20485 (I9018_20420) 4472582..4473127 - 546 WP_241107368.1 cytochrome b/b6 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4298305..4531064 232759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11134.74 Da        Isoelectric Point: 4.9313

>T183992 WP_277398076.1 NZ_CP066123:c4467930-4467637 [Pseudomonas sp. MPFS]
VPRLMLTEGAAQGLERCRQFLVEKGPLIAQRAAQVIERQIARLEEDPEIGRPFPELPELRELIIEFGDSGYVALYRHERA
DDAVYILAFRHQKEAGY

Download         Length: 294 bp

>T183992 NZ_CP087290:c1172939-1172532 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10539.74 Da        Isoelectric Point: 6.0850

>AT183992 WP_241107364.1 NZ_CP066123:c4468190-4467918 [Pseudomonas sp. MPFS]
MATSIKIDDELKKRIQHLAGLRQRSSHWIMREAIAQYVEREEAREGFKQEALASWAAYQETGRHLTGQETRDWLNTWGTE
AETELPKCHD

Download         Length: 273 bp

>AT183992 NZ_CP087290:c1173186-1172920 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References