Detailed information of TA system TA183991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2835250..2836472
• Replicon: chromosome
• Accession: NZ_CP066123
• Organism: Pseudomonas sp. MPFS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I9018_RS13425
• Protein ID: WP_241109738.1
• Coordinates: 2835900..2836472 (+)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I9018_RS13420
• Protein ID: WP_241109737.1
• Coordinates: 2835250..2835807 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9018_RS13390 (I9018_13380)	2830823..2831434	-	612	WP_241109733.1	AidA/PixA family protein	-
I9018_RS13395 (I9018_13385)	2831705..2832124	+	420	WP_068583854.1	helix-turn-helix domain-containing protein	-
I9018_RS13400 (I9018_13390)	2832121..2832996	+	876	WP_241109734.1	alpha/beta fold hydrolase	-
I9018_RS13405 (I9018_13395)	2832983..2833369	+	387	WP_068583860.1	DUF4180 domain-containing protein	-
I9018_RS13410 (I9018_13400)	2833518..2834696	+	1179	WP_241109735.1	PrpF domain-containing protein	-
I9018_RS13415 (I9018_13405)	2834749..2835078	-	330	WP_241109736.1	low molecular weight protein tyrosine phosphatase family protein	-
I9018_RS13420 (I9018_13410)	2835250..2835807	+	558	WP_241109737.1	helix-turn-helix transcriptional regulator	Antitoxin
I9018_RS13425 (I9018_13415)	2835900..2836472	+	573	WP_241109738.1	HD domain-containing protein	Toxin
I9018_RS13430 (I9018_13420)	2836550..2837164	-	615	WP_241109739.1	hypothetical protein	-
I9018_RS13435 (I9018_13425)	2837184..2838188	+	1005	WP_241109740.1	helix-turn-helix domain-containing protein	-
I9018_RS13440 (I9018_13430)	2838271..2838834	-	564	WP_241109741.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (10-187)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-49)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21617.26 Da
• Isoelectric Point: 5.8359

>T183991 WP_241109738.1 NZ_CP066123:2835900-2836472 [Pseudomonas sp. MPFS]
MNDQLLGGRLEFLRQAERLKDVLRSAHTSSGRQESTAEHSWRLCLMALLLEDQLGELDLLQVLKLCIVHDLGEALHGDIP
AVQQAAHPDKGQQEREDLQTLARCLDAPARQRLLALWDEYENASSAEARAVKALDKLETLVQHNQGRNPADFDYRFNLDY
GRRYTSATPLFRALREQIDHDTRRHIDAAG

Nucleotide

• Length: 573 bp

>T183991 NZ_CP087290:c735602-735204 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20414.34 Da
• Isoelectric Point: 7.0310

>AT183991 WP_241109737.1 NZ_CP066123:2835250-2835807 [Pseudomonas sp. MPFS]
MSASLFTSPHLGLALRRWRLLHRVKQQHAAELFGVAQSSISRWENGQQAMEPSERAKLEQLLAANLSVAADQALARLVND
SPRAVHLVCDLTHRLLACSPTRAGEFGVPLSELLGQSLWGFCTEEIVRKERALDDLGWREVLAPPALEFFSGHNDSAIVP
IAASQCRWTRLSLSDGNAVRLVETL

Nucleotide

• Length: 558 bp

>AT183991 NZ_CP087290:c735829-735602 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA