Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2635127..2635746 Replicon chromosome
Accession NZ_CP066123
Organism Pseudomonas sp. MPFS

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I9018_RS12475 Protein ID WP_124346520.1
Coordinates 2635564..2635746 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I9018_RS12470 Protein ID WP_241109627.1
Coordinates 2635127..2635528 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9018_RS12445 (I9018_12435) 2631119..2632309 + 1191 WP_241109624.1 MFS transporter -
I9018_RS12450 (I9018_12440) 2632461..2632682 - 222 Protein_2451 transposase -
I9018_RS12455 (I9018_12445) 2632684..2632791 - 108 Protein_2452 type II toxin-antitoxin system HicB family antitoxin -
I9018_RS12460 (I9018_12450) 2633770..2634114 + 345 WP_241109625.1 hypothetical protein -
I9018_RS12465 (I9018_12455) 2634291..2635061 + 771 WP_241109626.1 enterotoxin A family protein -
I9018_RS12470 (I9018_12460) 2635127..2635528 - 402 WP_241109627.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I9018_RS12475 (I9018_12465) 2635564..2635746 - 183 WP_124346520.1 type II toxin-antitoxin system HicA family toxin Toxin
I9018_RS12480 (I9018_12470) 2636301..2636582 - 282 WP_241109628.1 hypothetical protein -
I9018_RS12485 (I9018_12475) 2637712..2639127 - 1416 WP_241109629.1 hypothetical protein -
I9018_RS12490 (I9018_12480) 2639117..2640586 - 1470 WP_241109630.1 SMEK domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2628550..2641993 13443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6827.05 Da        Isoelectric Point: 11.6157

>T183990 WP_124346520.1 NZ_CP066123:c2635746-2635564 [Pseudomonas sp. MPFS]
VQSRQLIKELEAAGWILDRITGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAGLI

Download         Length: 183 bp

>T183990 NZ_CP087290:c249252-249001 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14572.59 Da        Isoelectric Point: 5.1405

>AT183990 WP_241109627.1 NZ_CP066123:c2635528-2635127 [Pseudomonas sp. MPFS]
MQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFESAYSAAIEIAHVMLEELARAGQAIPLPSPTHKHRANPDFAGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Download         Length: 402 bp

>AT183990 NZ_CP087290:c249004-248750 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References