Detailed information of TA system TA183990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2635127..2635746
• Replicon: chromosome
• Accession: NZ_CP066123
• Organism: Pseudomonas sp. MPFS

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: I9018_RS12475
• Protein ID: WP_124346520.1
• Coordinates: 2635564..2635746 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I9018_RS12470
• Protein ID: WP_241109627.1
• Coordinates: 2635127..2635528 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9018_RS12445 (I9018_12435)	2631119..2632309	+	1191	WP_241109624.1	MFS transporter	-
I9018_RS12450 (I9018_12440)	2632461..2632682	-	222	Protein_2451	transposase	-
I9018_RS12455 (I9018_12445)	2632684..2632791	-	108	Protein_2452	type II toxin-antitoxin system HicB family antitoxin	-
I9018_RS12460 (I9018_12450)	2633770..2634114	+	345	WP_241109625.1	hypothetical protein	-
I9018_RS12465 (I9018_12455)	2634291..2635061	+	771	WP_241109626.1	enterotoxin A family protein	-
I9018_RS12470 (I9018_12460)	2635127..2635528	-	402	WP_241109627.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I9018_RS12475 (I9018_12465)	2635564..2635746	-	183	WP_124346520.1	type II toxin-antitoxin system HicA family toxin	Toxin
I9018_RS12480 (I9018_12470)	2636301..2636582	-	282	WP_241109628.1	hypothetical protein	-
I9018_RS12485 (I9018_12475)	2637712..2639127	-	1416	WP_241109629.1	hypothetical protein	-
I9018_RS12490 (I9018_12480)	2639117..2640586	-	1470	WP_241109630.1	SMEK domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2628550..2641993	13443

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6827.05 Da
• Isoelectric Point: 11.6157

>T183990 WP_124346520.1 NZ_CP066123:c2635746-2635564 [Pseudomonas sp. MPFS]
VQSRQLIKELEAAGWILDRITGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAGLI

Nucleotide

• Length: 183 bp

>T183990 NZ_CP087290:c249252-249001 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14572.59 Da
• Isoelectric Point: 5.1405

>AT183990 WP_241109627.1 NZ_CP066123:c2635528-2635127 [Pseudomonas sp. MPFS]
MQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFESAYSAAIEIAHVMLEELARAGQAIPLPSPTHKHRANPDFAGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Nucleotide

• Length: 402 bp

>AT183990 NZ_CP087290:c249004-248750 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA