Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1582981..1583494 Replicon chromosome
Accession NZ_CP066123
Organism Pseudomonas sp. MPFS

Toxin (Protein)


Gene name relE Uniprot ID A0A6G6ZW42
Locus tag I9018_RS07240 Protein ID WP_068582176.1
Coordinates 1582981..1583265 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7X1FE57
Locus tag I9018_RS07245 Protein ID WP_068582179.1
Coordinates 1583255..1583494 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9018_RS07215 (I9018_07220) 1578066..1578953 - 888 WP_241109082.1 dihydrodipicolinate synthase family protein -
I9018_RS07220 (I9018_07225) 1578987..1579769 - 783 WP_068582166.1 aldolase -
I9018_RS07225 (I9018_07230) 1579931..1580473 + 543 WP_068582169.1 XRE family transcriptional regulator -
I9018_RS07230 (I9018_07235) 1580612..1581631 - 1020 WP_241110118.1 DUF4917 family protein -
I9018_RS07235 (I9018_07240) 1581789..1582937 + 1149 WP_241109083.1 L-threonine dehydrogenase -
I9018_RS07240 (I9018_07245) 1582981..1583265 - 285 WP_068582176.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I9018_RS07245 (I9018_07250) 1583255..1583494 - 240 WP_068582179.1 ribbon-helix-helix protein, CopG family Antitoxin
I9018_RS07250 (I9018_07255) 1583691..1584431 + 741 WP_124345966.1 hypothetical protein -
I9018_RS07255 (I9018_07260) 1584442..1585143 + 702 WP_241109084.1 hypothetical protein -
I9018_RS07260 (I9018_07265) 1585147..1585590 + 444 WP_068582188.1 fosfomycin resistance glutathione transferase -
I9018_RS07265 (I9018_07270) 1585692..1586330 + 639 WP_068582191.1 LysE family translocator -
I9018_RS07270 (I9018_07275) 1586440..1587789 + 1350 WP_068582196.1 GGDEF domain-containing protein -
I9018_RS07275 (I9018_07280) 1587913..1588437 + 525 WP_124345968.1 DUF4142 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11100.77 Da        Isoelectric Point: 11.5026

>T183989 WP_068582176.1 NZ_CP066123:c1583265-1582981 [Pseudomonas sp. MPFS]
MHIEWLRTALKNLDDEARYIAQDNPEAAREFVQTLLTGIGHLARFPASGREGRLPGTREWVVPGWPYLIPYRVRGSRLQI
LRIFHTRRQPPQRW

Download         Length: 285 bp

>T183989 NZ_CP087290:c249004-248750 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8537.68 Da        Isoelectric Point: 4.4143

>AT183989 WP_068582179.1 NZ_CP066123:c1583494-1583255 [Pseudomonas sp. MPFS]
MSIMSLRLPDEMAETLALLAKATGRSKSFLAVDALREYLAREAWQIEEIQKALGEADAGDFASAEEVAAITGKWTGNAH

Download         Length: 240 bp

>AT183989 NZ_CP087290:c249252-249001 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6ZW42

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1FE57

References