Detailed information of TA system TA183985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 188192..188708
• Replicon: chromosome
• Accession: NZ_CP066123
• Organism: Pseudomonas sp. MPFS

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I9018_RS00810
• Protein ID: WP_124345436.1
• Coordinates: 188427..188708 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I9018_RS00805
• Protein ID: WP_085598199.1
• Coordinates: 188192..188437 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9018_RS00790 (I9018_00785)	185671..187257	+	1587	WP_241108497.1	glycosyltransferase family 39 protein	-
I9018_RS00795 (I9018_00790)	187406..187867	+	462	WP_085598056.1	YbaK/EbsC family protein	-
I9018_RS00800 (I9018_00795)	187882..188130	+	249	WP_124345435.1	DUF2789 domain-containing protein	-
I9018_RS00805 (I9018_00800)	188192..188437	+	246	WP_085598199.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I9018_RS00810 (I9018_00805)	188427..188708	+	282	WP_124345436.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I9018_RS00815 (I9018_00810)	188840..189268	+	429	WP_241108498.1	winged helix DNA-binding protein	-
I9018_RS00820 (I9018_00815)	189265..191352	+	2088	WP_241108499.1	FUSC family protein	-
I9018_RS00825 (I9018_00820)	191349..191558	+	210	WP_022643266.1	DUF1656 domain-containing protein	-
I9018_RS00830 (I9018_00825)	191555..192445	+	891	WP_068576241.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-71)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10807.85 Da
• Isoelectric Point: 10.6758

>T183985 WP_124345436.1 NZ_CP066123:188427-188708 [Pseudomonas sp. MPFS]
MTYKLEFLPSALKEWNKLGHTLREQFKKKLAQRLQMPQVPADALYGLPDCYKIKLKASGYRLVYKVIEQRVVVAVVAVGK
RERGAVYEQARKR

Nucleotide

• Length: 282 bp

>T183985 NZ_CP087288:c164324-164019 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8759.08 Da
• Isoelectric Point: 4.3455

>AT183985 WP_085598199.1 NZ_CP066123:188192-188437 [Pseudomonas sp. MPFS]
MQSILADKAVSVSELKKNPSAVLNGAQGGPVAVLNHNRVMGYMIPAEVFEALMERLDDLELAEIVRARSQETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT183985 NZ_CP087288:c164544-164326 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA