Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2320497..2321242 Replicon chromosome
Accession NZ_CP066108
Organism Enterobacter hormaechei strain Eho-7

Toxin (Protein)


Gene name tacT Uniprot ID F5RXF6
Locus tag GVI68_RS11130 Protein ID WP_006810665.1
Coordinates 2320751..2321242 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7T1VGI8
Locus tag GVI68_RS11125 Protein ID WP_032673836.1
Coordinates 2320497..2320763 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI68_RS11105 (GVI68_11080) 2315974..2316960 + 987 WP_006810670.1 DUF979 domain-containing protein -
GVI68_RS11110 (GVI68_11085) 2316970..2317965 + 996 WP_006810669.1 DUF2891 domain-containing protein -
GVI68_RS11115 (GVI68_11090) 2317986..2319374 - 1389 WP_039273807.1 MFS transporter -
GVI68_RS11120 (GVI68_11095) 2319503..2320408 + 906 WP_032673837.1 LysR family transcriptional regulator -
GVI68_RS11125 (GVI68_11100) 2320497..2320763 + 267 WP_032673836.1 DUF1778 domain-containing protein Antitoxin
GVI68_RS11130 (GVI68_11105) 2320751..2321242 + 492 WP_006810665.1 GNAT family N-acetyltransferase Toxin
GVI68_RS11135 (GVI68_11110) 2321281..2322279 - 999 WP_006810664.1 HAD family hydrolase -
GVI68_RS11140 (GVI68_11115) 2322276..2323289 - 1014 WP_006810663.1 BatD family protein -
GVI68_RS11145 (GVI68_11120) 2323286..2324800 - 1515 WP_006810662.1 VWA domain-containing protein -
GVI68_RS11150 (GVI68_11125) 2324797..2325774 - 978 WP_039273812.1 VWA domain-containing protein -
GVI68_RS11155 (GVI68_11130) 2325767..2326207 - 441 WP_006810660.1 DUF4381 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(45-151)

Antitoxin

(6-82)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17773.46 Da        Isoelectric Point: 9.6044

>T183962 WP_006810665.1 NZ_CP066108:2320751-2321242 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGHLRRNM
PDPIPVIVLARLAVDVSLHGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTENAKAFYLHHGFKASQTQERTLFLRLP
QEK

Download         Length: 492 bp

>T183962 NZ_CP087287:307800-307973 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT183962 WP_032673836.1 NZ_CP066108:2320497-2320763 [Enterobacter hormaechei]
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT183962 NZ_CP087287:307476-307772 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7T1VG35


Antitoxin

Source ID Structure
AlphaFold DB A0A7T1VGI8

References