Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1117515..1118135 Replicon chromosome
Accession NZ_CP066108
Organism Enterobacter hormaechei strain Eho-7

Toxin (Protein)


Gene name Hha Uniprot ID F5RUW8
Locus tag GVI68_RS05360 Protein ID WP_001291436.1
Coordinates 1117515..1117733 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GVI68_RS05365 Protein ID WP_006809850.1
Coordinates 1117761..1118135 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI68_RS05325 (GVI68_05320) 1112740..1113546 - 807 WP_032673625.1 nickel/cobalt efflux protein RcnA -
GVI68_RS05330 (GVI68_05325) 1113681..1113953 + 273 WP_006809855.1 metal-sensing transcriptional repressor -
GVI68_RS05335 (GVI68_05330) 1113946..1115514 - 1569 WP_006809854.1 EAL domain-containing protein -
GVI68_RS05340 (GVI68_05335) 1115732..1115992 + 261 WP_006809853.1 type B 50S ribosomal protein L31 -
GVI68_RS05345 (GVI68_05340) 1115995..1116135 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GVI68_RS05350 (GVI68_05345) 1116171..1116638 - 468 WP_006809852.1 YlaC family protein -
GVI68_RS05355 (GVI68_05350) 1116755..1117306 - 552 WP_006809851.1 maltose O-acetyltransferase -
GVI68_RS05360 (GVI68_05355) 1117515..1117733 - 219 WP_001291436.1 HHA domain-containing protein Toxin
GVI68_RS05365 (GVI68_05360) 1117761..1118135 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GVI68_RS05370 (GVI68_05365) 1118644..1121790 - 3147 WP_006809849.1 multidrug efflux RND transporter permease subunit AcrB -
GVI68_RS05375 (GVI68_05370) 1121813..1123006 - 1194 WP_006809848.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T183959 WP_001291436.1 NZ_CP066108:c1117733-1117515 [Enterobacter hormaechei]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T183959 NZ_CP087282:c76068-75583 [Leclercia adecarboxylata]
GTGGGACGTGTAACAGCACCGGAACCGTTATCCAACTCACATCAACTGGCTGAGTTCGTCAGCGGGGAGGCCGTTCTCGA
TGACTGGCTTAAACAGAGAGGGTTAAAAAATCAGGCTCTTGGTGCTGCCAGAACGTTCGTTGTTTGTAAAACAGGTACCA
AACTGGTTGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATGTAGAAGCCACTGGAAGTCTCAGGCGCAATATG
CCTGATCCAATCCCAGTAATCATACTTGCTCGCCTGGCTGTCGATGTCTCATTCCGTGGAAAAGGGCTGGGTGCTGATTT
ACTCCACGATGCAGTATTGCGCTGTTATCGGGTCGCAGACAATATAGGCGTCCGTGCGATTATGGTTCATGCTCTGACAG
AACAAGCCAAAAGTTTTTATCTTCACCATGGTTTTAAAGCATCGCAAACCCAGGAGCGAACTCTGTTTCTCAAATTACCA
CAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT183959 WP_006809850.1 NZ_CP066108:c1118135-1117761 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT183959 NZ_CP087282:c76322-76056 [Leclercia adecarboxylata]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCTCAAAGGGCACTCATTGATGCTGCTGCAGAGATCCTCCA
TAAATCACGTACGGACTTCATTCTGGAAATGGCATGCCAGGCTGCGGAAAATGTGATCCTCGACCGGCGCGTATTTAATT
TTAATGATGAGCAGTACGCAGAGTTTATCGACATGCTCGATGCACCAGTTGCAAATGACGCGGCAATCAATAAACTCCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VNQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References