Detailed information of TA system TA183957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 66608..67264
• Replicon: chromosome
• Accession: NZ_CP066108
• Organism: Enterobacter hormaechei strain Eho-7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GVI68_RS00340
• Protein ID: WP_006812483.1
• Coordinates: 66872..67264 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: F5S3Q5
• Locus tag: GVI68_RS00335
• Protein ID: WP_006812484.1
• Coordinates: 66608..66868 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GVI68_RS00305 (GVI68_00305)	61809..62123	-	315	WP_006812490.1	PTS sugar transporter subunit IIB	-
GVI68_RS00310 (GVI68_00310)	62417..63367	+	951	WP_006812489.1	LacI family DNA-binding transcriptional regulator	-
GVI68_RS00315 (GVI68_00315)	63415..63711	-	297	WP_003861030.1	YicS family protein	-
GVI68_RS00320 (GVI68_00320)	63849..64268	+	420	WP_006812487.1	GNAT family N-acetyltransferase	-
GVI68_RS00325 (GVI68_00325)	64265..64912	-	648	WP_006812486.1	TetR/AcrR family transcriptional regulator	-
GVI68_RS00330 (GVI68_00330)	64991..66490	+	1500	WP_039272833.1	MDR family MFS transporter	-
GVI68_RS00335 (GVI68_00335)	66608..66868	+	261	WP_006812484.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GVI68_RS00340 (GVI68_00340)	66872..67264	+	393	WP_006812483.1	type II toxin-antitoxin system VapC family toxin	Toxin
GVI68_RS00345 (GVI68_00345)	67333..67806	-	474	WP_032674176.1	hypothetical protein	-
GVI68_RS00350 (GVI68_00350)	68188..68988	+	801	WP_032674175.1	lipoprotein NlpA	-
GVI68_RS00355 (GVI68_00355)	69022..69702	-	681	WP_000288876.1	EAL domain-containing protein	-
GVI68_RS00360 (GVI68_00360)	69778..70398	-	621	WP_006812480.1	LuxR C-terminal-related transcriptional regulator	-
GVI68_RS00365 (GVI68_00365)	71102..71602	+	501	WP_237892367.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14587.75 Da
• Isoelectric Point: 5.8985

>T183957 WP_006812483.1 NZ_CP066108:66872-67264 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITICAWDSEAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTQ

Nucleotide

• Length: 393 bp

>T183957 NZ_CP087281:c70894-70478 [Leclercia adecarboxylata]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10169.45 Da
• Isoelectric Point: 9.7289

>AT183957 WP_006812484.1 NZ_CP066108:66608-66868 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKERHRDNFLRMLRQTHVPDTFLSKEERNQSYTTR
NPLEGL

Nucleotide

• Length: 261 bp

>AT183957 NZ_CP087281:c71121-70891 [Leclercia adecarboxylata]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7T1QFB1