Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 7648..8249 Replicon plasmid pEho8-4
Accession NZ_CP066105
Organism Enterobacter hormaechei strain Eho-8

Toxin (Protein)


Gene name hicA Uniprot ID A0A7T1VMP0
Locus tag GVI69_RS24395 Protein ID WP_045284289.1
Coordinates 7986..8249 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7T1QNY9
Locus tag GVI69_RS24390 Protein ID WP_045284288.1
Coordinates 7648..7989 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI69_RS24380 (GVI69_24295) 2708..5597 + 2890 Protein_7 Tn3 family transposase -
GVI69_RS24500 6062..6184 - 123 WP_258364704.1 hypothetical protein -
GVI69_RS24385 (GVI69_24300) 6937..7224 - 288 WP_045284286.1 hypothetical protein -
GVI69_RS24390 (GVI69_24305) 7648..7989 - 342 WP_045284288.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GVI69_RS24395 (GVI69_24310) 7986..8249 - 264 WP_045284289.1 type II toxin-antitoxin system HicA family toxin Toxin
GVI69_RS24400 (GVI69_24315) 8385..8687 - 303 WP_228059344.1 single-stranded DNA-binding protein -
GVI69_RS24405 (GVI69_24320) 8795..11650 - 2856 WP_045284290.1 VapE family protein -
GVI69_RS24410 (GVI69_24325) 11661..11951 - 291 WP_045289091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..15459 15459
- flank IS/Tn - - 2708..5563 2855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-76)

Antitoxin

Uncharacterised protein family HicB

(55-101)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9920.42 Da        Isoelectric Point: 10.6082

>T183956 WP_045284289.1 NZ_CP066105:c8249-7986 [Enterobacter hormaechei]
MTLRKQHQRTLEAIYRRPVSGTIEYKDFKALMLALGAELDESAAGSREGFTLRGEPRVFHRPHPKSTMDKGAVSEARQWL
ERLGIKP

Download         Length: 264 bp

>T183956 NZ_CP087280:c3935643-3935230 [Leclercia adecarboxylata]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCGTGGCGCGCCCAGTGGATGTCTCTTTTGCTCCACGGCCTGGTTGCGGC
TTGCATCCTGTTGATACCATGGCCGCTAAGCTACACCCCGTTATGGTTAATTTTACTGTCGCTGGTGGTGTTTGACAGCG
TACGCAGCCAACGGCGCATCAATTCCCGTCAGGGCGAAATCAAGCTATTCATGGATTCCCGCCTGCAGTGGCAGGGTAGC
GAGTGGGAGATTATCGGTACGCCGTGGATGCTCAATTCCGGCATGATGCTCCGCTTACGCAAGGGCGACGGGAAACGCTA
CCAGCATTTGTGGTTGTCGGCAGACAGCATGGATGAAGGGGAGTGGCGGGATCTGCGCCGGATGCTTTCGCAGCAACCGA
CGCACGGGCGGTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12602.23 Da        Isoelectric Point: 5.2005

>AT183956 WP_045284288.1 NZ_CP066105:c7989-7648 [Enterobacter hormaechei]
MINVMKVNGHAATVAFDPEIEMFRGSFVGLTGGADFYARTVEELHREGAESLRFYLEICEKRGIEPYKAYSGKVSTRLTP
ERHQALEQIAAAHGESINQLLNEGADLVIERYA

Download         Length: 342 bp

>AT183956 NZ_CP087280:c3935890-3935624 [Leclercia adecarboxylata]
ATGGACATTACTAACAAAGCCCGCATTCATTGGGCATGCCGTCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
CTTCGAATACGAATACGACACCCTGAGCGATGAGGATAAAAAGCTGTTTATCCGCCTGCTGGAGAACGACGATCCTGATT
TATTTAACTGGTTAATGAATCACGGCGAACCTGCCGACGCCGAACTGCAACGGATGGTGCTTTTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VMP0

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1QNY9

References