Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3634390..3635047 Replicon chromosome
Accession NZ_CP066101
Organism Enterobacter hormaechei strain Eho-8

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1QL73
Locus tag GVI69_RS17345 Protein ID WP_032674037.1
Coordinates 3634390..3634800 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag GVI69_RS17350 Protein ID WP_003863437.1
Coordinates 3634781..3635047 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI69_RS17325 (GVI69_17280) 3630388..3632121 - 1734 WP_006811870.1 single-stranded-DNA-specific exonuclease RecJ -
GVI69_RS17330 (GVI69_17285) 3632127..3632840 - 714 WP_006811871.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GVI69_RS17335 (GVI69_17290) 3632869..3633765 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
GVI69_RS17340 (GVI69_17295) 3633867..3634388 + 522 WP_006811872.1 flavodoxin FldB -
GVI69_RS17345 (GVI69_17300) 3634390..3634800 - 411 WP_032674037.1 protein YgfX Toxin
GVI69_RS17350 (GVI69_17305) 3634781..3635047 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
GVI69_RS17355 (GVI69_17310) 3635342..3636322 + 981 WP_006811874.1 tRNA-modifying protein YgfZ -
GVI69_RS17360 (GVI69_17315) 3636407..3637066 - 660 WP_006811875.1 hemolysin III family protein -
GVI69_RS17365 (GVI69_17320) 3637333..3638064 + 732 WP_006811877.1 MurR/RpiR family transcriptional regulator -
GVI69_RS17370 (GVI69_17325) 3638181..3639614 + 1434 WP_006811878.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16292.10 Da        Isoelectric Point: 11.1558

>T183952 WP_032674037.1 NZ_CP066101:c3634800-3634390 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMTGTPWMLNTGMMLRLRRVEDNRREHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T183952 NZ_CP087280:c1168752-1168390 [Leclercia adecarboxylata]
ATGTGGGAAGTCGAAACAACGGATACGTTTGACAAGTGGTTTAACCACCAGTCACAAGCCTTGAAAGAAGATGTCCTGGC
TATAATGCATATCCTCTCAGAGTACGGTCCACAGCTGGGCCGTCCCTGGGTCGATACAGTTAAAAACTCACATTACGCGA
ATATGAAAGAGCTACGCATTCAGCATGCAGGGGATCCGGTTCGTGCTTTTTTTGCCTTCGATCCTGGTCGTAAAGCCATA
ATTTTATGTGCTGGAAATAAGACGGGAAAAAATGAAAAGCGATTCTATAAAGATATGATCACCATGGCTGATGCTGAATT
CAGCGATTATCTGGCGAGTAAGGAGGCCGAATGGCTACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT183952 WP_003863437.1 NZ_CP066101:c3635047-3634781 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT183952 NZ_CP087280:c1168402-1168103 [Leclercia adecarboxylata]
ATGGCTACGTTAAAAGAACTCATGGCCCAGCAGAGCCAGGAAAGTCAGGAGCGAATTGCCGCTAAAGTTGAGGATCTGCG
CATTATTGTCGCGCTCAACCAGCTCCGGGAAGAACTCAACATATCGCAAACTGAACTTGCTGCCGCGATGGGGGTTAAAC
AGCCTACCGTTGCGAAAATTGAGCAACCGGATAATGATCCGCGTCTTTCTACGCTTAAACGCTATGTTACGGCATTAGGG
GGTGAAGTGAGTATTGATGTCATTCTGCCCACCGGGAAGCGGGTGGCGTTTCATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1QL73

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References